Curated Information
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Home > Curated Information Page > PubMed Id: 19146852
Li C, Chen CJ, Shively JE (2009) Mutational analysis of the cytoplasmic domain of CEACAM1-4L in humanized mammary glands reveals key residues involved in lumen formation: stimulation by Thr-457 and inhibition by Ser-461. Exp Cell Res 315, 1225-33 19146852
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T457-p - CEACAM1 (human)
Modsite: CFLHFGKtGRAsDQR SwissProt Entrez-Gene
Orthologous residues
CEACAM1 (human): T457‑p, CEACAM1 iso8 (human): T457‑p, CEACAM1 iso9 (human): T392‑p, CEACAM1 (mouse): S452‑p, CEACAM1 (rat): T452‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) [CEACAM1 (human), transfection]
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  apoptosis, altered
Comments:  blocks formation of lumen

S461-p - CEACAM1 (human)
Modsite: FGKtGRAsDQRDLTE SwissProt Entrez-Gene
Orthologous residues
CEACAM1 (human): S461‑p, CEACAM1 iso8 (human): , CEACAM1 iso9 (human): , CEACAM1 (mouse): S456‑p, CEACAM1 (rat): S456‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Disease tissue studied:  breast cancer
Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) [CEACAM1 (human), transfection]
Cellular systems studied:  cell lines
Downstream Regulation
Effect of modification (function):  activity, inhibited
Effect of modification (process):  apoptosis, altered
Comments:  blocks formation of lumen