Li C, Chen CJ, Shively JE (2009) Mutational analysis of the cytoplasmic domain of CEACAM1-4L in humanized mammary glands reveals key residues involved in lumen formation: stimulation by Thr-457 and inhibition by Ser-461. Exp Cell Res 315, 1225-33 19146852

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T457-p - CEACAM1 (human) ▲

Modsite: CFLHFGKtGRAsDQR SwissProt Entrez-Gene Orthologous residues CEACAM1 (human): T457‑p, CEACAM1 iso8 (human): T457‑p, CEACAM1 iso9 (human): T392‑p, CEACAM1 (mouse): S452‑p, CEACAM1 (rat): T452‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) [CEACAM1 (human), transfection] Cellular systems studied:  cell lines Downstream Regulation Effect of modification (function):  activity, inhibited Effect of modification (process):  apoptosis, altered Comments:  blocks formation of lumen

S461-p - CEACAM1 (human) ▲

Modsite: FGKtGRAsDQRDLTE SwissProt Entrez-Gene Orthologous residues CEACAM1 (human): S461‑p, CEACAM1 iso8 (human): ‑, CEACAM1 iso9 (human): ‑, CEACAM1 (mouse): S456‑p, CEACAM1 (rat): S456‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  breast cancer Relevant cell lines - cell types - tissues:  MCF-7 (breast cell) [CEACAM1 (human), transfection] Cellular systems studied:  cell lines Downstream Regulation Effect of modification (function):  activity, inhibited Effect of modification (process):  apoptosis, altered Comments:  blocks formation of lumen