Nishi A, et al. (2008) Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum. J Neurosci 28, 10460-71 18923023

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T34-p - DARPP-32 (mouse) ▲

Modsite: MIRRRRPtPAMLFRV SwissProt Entrez-Gene Orthologous residues DARPP‑32 (human): T34‑p, DARPP‑32 iso2 (human): ‑, DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes papaverine increase SCH_23390 papaverine inhibit treatment-induced increase ZM241385 papaverine inhibit treatment-induced increase ODQ papaverine no effect upon treatment-induced increase quinpirole papaverine inhibit treatment-induced increase raclopride papaverine no effect upon treatment-induced increase CGS_21680 increase rolipram CGS_21680 augment treatment-induced increase SKF81297 increase rolipram SKF81297 inhibit treatment-induced increase rolipram no change compared to control CGS_21680 increase slight increase SKF81297 increase slight increase papaverine increase CGS_21680 papaverine augment treatment-induced increase SKF81297 papaverine augment treatment-induced increase

T183-p - ERK2 (mouse) ▲

Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene Orthologous residues ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes papaverine increase rolipram no change compared to control

Y185-p - ERK2 (mouse) ▲

Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene Orthologous residues ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes papaverine increase rolipram no change compared to control

S863-p - GluR1 (mouse) ▲

Modsite: TSTLPRNsGAGASGG SwissProt Entrez-Gene Orthologous residues GluR1 (human): S863‑p, GluR1 iso6 (human): S873‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes haloperidol increase small increase papaverine haloperidol augment treatment-induced increase rolipram haloperidol augment treatment-induced increase papaverine no change compared to control striatum in vivo rolipram no change compared to control

S9-p - SYN1 (mouse) ▲

Modsite: NYLRRRLsDSNFMAN SwissProt Entrez-Gene Orthologous residues SYN1 (human): S9‑p, SYN1 iso2 (human): S9‑p, SYN1 (mouse): S9‑p, SYN1 iso1 (mouse): S9‑p, SYN1 iso3 (mouse): S9‑p, SYN1 (rat): S9‑p, SYN1 (cow): S9‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes papaverine increase rolipram increase

S40-p - TH (mouse) ▲

Modsite: RFIGRRQsLIEDARK SwissProt Entrez-Gene Orthologous residues TH (human): S71‑p, TH iso2 (human): S67‑p, TH iso3 (human): S40‑p, TH iso4 (human): S44‑p, TH (mouse): S40‑p, TH (rat): S40‑p, TH (cow): S40‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, striatum' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes papaverine increase rolipram increase haloperidol increase papaverine haloperidol no effect upon treatment-induced increase rolipram haloperidol augment treatment-induced increase papaverine no change compared to control rolipram no change compared to control