Curated Information
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Home > Curated Information Page > PubMed Id: 10037602
Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-8 10037602
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T48-p - CDC25C (human)
Modsite: VCPDVPRtPVGkFLG SwissProt Entrez-Gene
Orthologous residues
CDC25C (human): T48‑p, CDC25C iso3 (human): T48‑p, CDC25C (mouse): S48‑p, CDC25C (frog): T48‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) WW Induces molecular association, regulation in vitro, pull-down assay
NEDD4 (mouse) WW Induces molecular association, regulation in vitro, pull-down assay
Comments:  WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

T67-p - CDC25C (human)
Modsite: LsILsGGtPkRCLDL SwissProt Entrez-Gene
Orthologous residues
CDC25C (human): T67‑p, CDC25C iso3 (human): , CDC25C (mouse): T66‑p, CDC25C (frog): T67‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) WW Induces molecular association, regulation in vitro, pull-down assay
NEDD4 (mouse) WW Induces molecular association, regulation in vitro, pull-down assay
Comments:  WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

S16-p - PIN1 (human)
Modsite: PGWEkRMsRSSGRVy SwissProt Entrez-Gene
Orthologous residues
PIN1 (human): S16‑p, PIN1 (mouse): S16‑p, PIN1 (rat): S16‑p

Y23-p - PIN1 (human)
Modsite: sRSSGRVyYFNHITN SwissProt Entrez-Gene
Orthologous residues
PIN1 (human): Y23‑p, PIN1 (mouse): Y23‑p, PIN1 (rat): Y23‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Comments:  regulates association to phosphopeptides