Curated Information
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Home > Curated Information Page > PubMed Id: 15886098
Hu H, Bliss JM, Wang Y, Colicelli J (2005) RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol 15, 815-23 15886098
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y35-p - Rin1 (mouse)
Modsite: KPstDPLyDTPDTRG SwissProt Entrez-Gene
Orthologous residues
Rin1 (human): Y36‑p, Rin1 iso2 (human): Y36‑p, Rin1 (mouse): Y35‑p, Rin1 (rat): Y35‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Arg (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme, phospho-antibody, transfection of inactive enzyme, genetic knockout/knockin of upstream enzyme
KINASE Abl (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme, phospho-antibody, transfection of inactive enzyme, genetic knockout/knockin of upstream enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Arg (human) Induces enzymatic activity, induced cytoskeletal reorganization co-immunoprecipitation

Y120-p - Rin1 (mouse)
Modsite: PSFVSSHyIEESTGG SwissProt Entrez-Gene
Orthologous residues
Rin1 (human): Y121‑p, Rin1 iso2 (human): Y121‑p, Rin1 (mouse): Y120‑p, Rin1 (rat): Y120‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Arg (human) Induces enzymatic activity, induced cytoskeletal reorganization co-immunoprecipitation

Y147-p - Rin1 (mouse)
Modsite: LVQLICGyCRTRAIH SwissProt Entrez-Gene
Orthologous residues
Rin1 (human): Y148‑p, Rin1 iso2 (human): Y148‑p, Rin1 (mouse): Y147‑p, Rin1 (rat): Y147‑p
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Arg (human) Induces enzymatic activity, induced cytoskeletal reorganization co-immunoprecipitation

Y222-p - CRK (chicken)
Modsite: GGPEPGPyAQPSINT SwissProt Entrez-Gene
Orthologous residues
CRK (human): Y221‑p, CRK iso2 (human): , CRK (mouse): Y221‑p, CRK iso3 (mouse): , CRK (rat): Y221‑p, CRK (chicken): Y222‑p
Characterization
Enzymes shown to modify site in vitro
Type Enzyme
KINASE Arg (human)
Comments:  Upregulated by addition of Rin1 in a concentration dependent manner.