Bhave G, et al. (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35, 721-31 12194871

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S6-p - TRPV1 (rat) ▲
Modsite: __MEQRAsLDSEESE SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S6‑p, TRPV1 (mouse): S6‑p, TRPV1 (rat): S6‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)

S116-p - TRPV1 (rat) ▲

Modsite: PRLYDRRsIFDAVAQ SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S117‑p, TRPV1 (mouse): S117‑p, TRPV1 (rat): S116‑p Characterization Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site Cellular systems studied:  cell lines Species studied:  green monkey, hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow) Downstream Regulation Effect of modification (function):  receptor desensitization, altered

T144-p - TRPV1 (rat) ▲
Modsite: QRSKKRLtDSEFKDP SwissProt Entrez-Gene Orthologous residues TRPV1 (human): T145‑p, TRPV1 (mouse): T145‑p, TRPV1 (rat): T144‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)

T370-p - TRPV1 (rat) ▲
Modsite: RHLSRKFtEWAYGPV SwissProt Entrez-Gene Orthologous residues TRPV1 (human): T371‑p, TRPV1 (mouse): T371‑p, TRPV1 (rat): T370‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)

S502-p - TRPV1 (rat) ▲
Modsite: YFLQRRPsLKSLFVD SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S502‑p, TRPV1 (mouse): S503‑p, TRPV1 (rat): S502‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)

S774-p - TRPV1 (rat) ▲
Modsite: EGVKRTLsFSLRSGR SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S775‑p, TRPV1 (mouse): S775‑p, TRPV1 (rat): S774‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)

S820-p - TRPV1 (rat) ▲
Modsite: QLKHYTGsLkPEDAE SwissProt Entrez-Gene Orthologous residues TRPV1 (human): S821‑p, TRPV1 (mouse): S821‑p, TRPV1 (rat): S820‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Cellular systems studied:  cell lines Species studied:  hamster Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKACA (cow)