Curated Information
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Home > Curated Information Page > PubMed Id: 27929080
Coricor G, Serra R (2016) TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms. Sci Rep 6, 38616 27929080
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S64-p - SOX9 (human)
Modsite: EPDLkKEsEEDkFPV SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): S64‑p, SOX9 (mouse): S64‑p, SOX9 (rat): S64‑p, SOX9 (chicken): S64‑p

S181-p - SOX9 (human)
Modsite: YQPRRRKsVKNGQAE SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): S181‑p, SOX9 (mouse): S181‑p, SOX9 (rat): S181‑p, SOX9 (chicken): S181‑p

S211-p - SOX9 (human)
Modsite: FKALQADsPHsSSGM SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): S211‑p, SOX9 (mouse): S211‑p, SOX9 (rat): S211‑p, SOX9 (chicken): S211‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE P38A (human) modification site within consensus motif, pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
SB203580 TGF-beta inhibit treatment-induced increase
SB202190 TGF-beta inhibit treatment-induced increase
SMAD2 (human), SMAD3 (human) increase SMAD2/3 siRNA inhibits
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  transcription, induced
Comments:  PAPSS2 mRNA expression