Curated Information
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Home > Curated Information Page > PubMed Id: 28009299
Plaza-Menacho I, et al. (2016) RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements. Cell Rep 17, 3319-3332 28009299
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y687-p - Ret (human)
Modsite: AQAFPVsysSSGARR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y687‑p, Ret iso2 (human): Y687‑p, Ret iso3 (human): , Ret (mouse): Y688‑p, Ret iso2 (mouse): Y688‑p, Ret iso4 (mouse): Y637‑p, Ret (rat): Y688‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, protein conformation

Y809-p - Ret (human)
Modsite: LIVEyAKyGSLRGFL SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y809‑p, Ret iso2 (human): Y809‑p, Ret iso3 (human): Y333‑p, Ret (mouse): Y810‑p, Ret iso2 (mouse): Y810‑p, Ret iso4 (mouse): Y759‑p, Ret (rat): Y810‑p

Y826-p - Ret (human)
Modsite: SRKVGPGyLGSGGSR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y826‑p, Ret iso2 (human): Y826‑p, Ret iso3 (human): Y350‑p, Ret (mouse): Y827‑p, Ret iso2 (mouse): Y827‑p, Ret iso4 (mouse): Y776‑p, Ret (rat): Y827‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y900-p - Ret (human)
Modsite: FGLSRDVyEEDsyVK SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y900‑p, Ret iso2 (human): Y900‑p, Ret iso3 (human): Y424‑p, Ret (mouse): Y901‑p, Ret iso2 (mouse): Y901‑p, Ret iso4 (mouse): , Ret (rat): Y901‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

Y905-p - Ret (human)
Modsite: DVyEEDsyVKRsQGR SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y905‑p, Ret iso2 (human): Y905‑p, Ret iso3 (human): Y429‑p, Ret (mouse): Y906‑p, Ret iso2 (mouse): Y906‑p, Ret iso4 (mouse): , Ret (rat): Y906‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced

S909-p - Ret (human)
Modsite: EDsyVKRsQGRIPVK SwissProt Entrez-Gene
Orthologous residues
Ret (human): S909‑p, Ret iso2 (human): S909‑p, Ret iso3 (human): S433‑p, Ret (mouse): S910‑p, Ret iso2 (mouse): S910‑p, Ret iso4 (mouse): , Ret (rat): S910‑p
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced
Comments:  Dual-speci¿city kinase activity

Y928-p - Ret (human)
Modsite: ESLFDHIyTTQSDVW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y928‑p, Ret iso2 (human): Y928‑p, Ret iso3 (human): Y452‑p, Ret (mouse): Y929‑p, Ret iso2 (mouse): Y929‑p, Ret iso4 (mouse): , Ret (rat): Y929‑p

Y981-p - Ret (human)
Modsite: DNCSEEMyRLMLQCW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y981‑p, Ret iso2 (human): Y981‑p, Ret iso3 (human): Y505‑p, Ret (mouse): Y982‑p, Ret iso2 (mouse): Y982‑p, Ret iso4 (mouse): , Ret (rat): Y982‑p

Y1015-p - Ret (human)
Modsite: MMVKRRDyLDLAAST SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1015‑p, Ret iso2 (human): Y1015‑p, Ret iso3 (human): Y539‑p, Ret (mouse): Y1016‑p, Ret iso2 (mouse): Y1016‑p, Ret iso4 (mouse): , Ret (rat): Y1016‑p

Y1062-p - Ret (human)
Modsite: TWIENkLyGMsDPNW SwissProt Entrez-Gene
Orthologous residues
Ret (human): Y1062‑p, Ret iso2 (human): Y1062‑p, Ret iso3 (human): Y586‑p, Ret (mouse): Y1063‑p, Ret iso2 (mouse): Y1063‑p, Ret iso4 (mouse): , Ret (rat): Y1063‑p