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Home > Curated Information Page > PubMed Id: 27992402
Liu B, et al. (2017) The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol 18, 214-224 27992402
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S396-p - IRF3 (human)
Modsite: NtVDLHIsNsHPLsL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S396‑p, IRF3 (mouse): S388‑p, IRF3 (rat): S390‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

S398-p - IRF3 (human)
Modsite: VDLHIsNsHPLsLts SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S398‑p, IRF3 (mouse): S390‑p, IRF3 (rat): S392‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

S402-p - IRF3 (human)
Modsite: IsNsHPLsLtsDQYK SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S402‑p, IRF3 (mouse): S394‑p, IRF3 (rat): S396‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

T404-p - IRF3 (human)
Modsite: NsHPLsLtsDQYKAY SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): T404‑p, IRF3 (mouse): T396‑p, IRF3 (rat): T398‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

S405-p - IRF3 (human)
Modsite: sHPLsLtsDQYKAYL SwissProt Entrez-Gene
Orthologous residues
IRF3 (human): S405‑p, IRF3 (mouse): S397‑p, IRF3 (rat): S399‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Downstream Regulation
Effect of modification (process):  transcription, induced

K10-ub - MAVS (human)
Modsite: FAEDkTykyICRNFS SwissProt Entrez-Gene
Orthologous residues
MAVS (human): K10‑ub, MAVS iso4 (human): , MAVS (mouse): K10‑ub, MAVS (rat): K10‑ub, MAVS (cow): E10‑ub
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE TRIM31 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAVS (human) Induces

K311-ub - MAVS (human)
Modsite: PVNtVALkVPANPAS SwissProt Entrez-Gene
Orthologous residues
MAVS (human): K311‑ub, MAVS iso4 (human): K170‑ub, MAVS (mouse): , MAVS (rat): , MAVS (cow): K292‑ub
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE TRIM31 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAVS (human) Induces

K461-ub - MAVS (human)
Modsite: GPEENEYkSEGTFGI SwissProt Entrez-Gene
Orthologous residues
MAVS (human): K461‑ub, MAVS iso4 (human): K320‑ub, MAVS (mouse): S437‑ub, MAVS (rat): S441‑ub, MAVS (cow): V452‑ub
Characterization
Methods used to characterize site in vivo modification-specific antibody, mutation of modification site
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
UBIQUITIN LIGASE TRIM31 (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MAVS (human) Induces