Liu B, et al. (2017) The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol 18, 214-224 27992402

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S396-p - IRF3 (human) ▲

Modsite: NtVDLHIsNsHPLsL SwissProt Entrez-Gene Orthologous residues IRF3 (human): S396‑p, IRF3 (mouse): S388‑p, IRF3 (rat): S390‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

S398-p - IRF3 (human) ▲

Modsite: VDLHIsNsHPLsLts SwissProt Entrez-Gene Orthologous residues IRF3 (human): S398‑p, IRF3 (mouse): S390‑p, IRF3 (rat): S392‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

S402-p - IRF3 (human) ▲

Modsite: IsNsHPLsLtsDQYK SwissProt Entrez-Gene Orthologous residues IRF3 (human): S402‑p, IRF3 (mouse): S394‑p, IRF3 (rat): S396‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

T404-p - IRF3 (human) ▲

Modsite: NsHPLsLtsDQYKAY SwissProt Entrez-Gene Orthologous residues IRF3 (human): T404‑p, IRF3 (mouse): T396‑p, IRF3 (rat): T398‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

S405-p - IRF3 (human) ▲

Modsite: sHPLsLtsDQYKAYL SwissProt Entrez-Gene Orthologous residues IRF3 (human): S405‑p, IRF3 (mouse): S397‑p, IRF3 (rat): S399‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (process):  transcription, induced

K10-ub - MAVS (human) ▲

Modsite: FAEDkTykyICRNFS SwissProt Entrez-Gene Orthologous residues MAVS (human): K10‑ub, MAVS iso4 (human): ‑, MAVS (mouse): K10‑ub, MAVS (rat): K10‑ub, MAVS (cow): E10‑ub Characterization Methods used to characterize site in vivo:  modification-specific antibody, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme UBIQUITIN LIGASE TRIM31 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays MAVS (human) Induces

K311-ub - MAVS (human) ▲

Modsite: PVNtVALkVPANPAS SwissProt Entrez-Gene Orthologous residues MAVS (human): K311‑ub, MAVS iso4 (human): K170‑ub, MAVS (mouse): ‑, MAVS (rat): ‑, MAVS (cow): K292‑ub Characterization Methods used to characterize site in vivo:  modification-specific antibody, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme UBIQUITIN LIGASE TRIM31 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays MAVS (human) Induces

K461-ub - MAVS (human) ▲

Modsite: GPEENEYkSEGTFGI SwissProt Entrez-Gene Orthologous residues MAVS (human): K461‑ub, MAVS iso4 (human): K320‑ub, MAVS (mouse): S437‑ub, MAVS (rat): S441‑ub, MAVS (cow): V452‑ub Characterization Methods used to characterize site in vivo:  modification-specific antibody, mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme UBIQUITIN LIGASE TRIM31 (human) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays MAVS (human) Induces