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Home > Curated Information Page > PubMed Id: 18725415
Samayawardhena LA, Pallen CJ (2008) Protein-tyrosine phosphatase alpha regulates stem cell factor-dependent c-Kit activation and migration of mast cells. J Biol Chem 283, 29175-85 18725415
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S473-p - Akt1 (mouse)
Modsite: RPHFPQFsysAsGtA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF increase PTPRA -/-

T203-p - ERK1 (mouse)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y205-p - ERK1 (mouse)
Modsite: HtGFLtEyVAtRWyR SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

T183-p - ERK2 (mouse)
Modsite: HDHtGFLtEyVAtRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y185-p - ERK2 (mouse)
Modsite: HtGFLtEyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y531-p - Fyn (mouse)
Modsite: FTATEPQyQPGENL_ SwissProt Entrez-Gene
Orthologous residues
Fyn (human): Y531‑p, Fyn iso2 (human): Y528‑p, Fyn iso3 (human): Y476‑p, Fyn (mouse): Y531‑p, Fyn (rat): Y531‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF decrease PTPRA WT
SCF increase PTPRA -/-

Y441-p - GAB2 (mouse)
Modsite: SASSDDNyVPMNPGS SwissProt Entrez-Gene
Orthologous residues
GAB2 (human): Y452‑p, GAB2 iso2 (human): Y414‑p, GAB2 (mouse): Y441‑p, GAB2 (rat): Y441‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

T183-p - JNK1 (mouse)
Modsite: AGtsFMMtPyVVtRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

Y185-p - JNK1 (mouse)
Modsite: tsFMMtPyVVtRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

Y571-p - Kit (mouse)
Modsite: EEINGNNyVyIDPTQ SwissProt Entrez-Gene
Orthologous residues
Kit (human): Y568‑p, Kit (mouse): Y571‑p, Kit (rat): Y570‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase WT PTPRA
SCF decrease PTPRA -/-
SU6656 SCF inhibit treatment-induced increase
SU6656 SCF augment treatment-induced decrease
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y573-p - Kit (mouse)
Modsite: INGNNyVyIDPTQLP SwissProt Entrez-Gene
Orthologous residues
Kit (human): Y570‑p, Kit (mouse): Y573‑p, Kit (rat): Y572‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase WT PTPRA
SCF decrease PTPRA -/-
SU6656 SCF inhibit treatment-induced increase
SU6656 SCF augment treatment-induced decrease
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y723-p - Kit (mouse)
Modsite: sCDSsNEyMDMKPGV SwissProt Entrez-Gene
Orthologous residues
Kit (human): Y721‑p, Kit (mouse): Y723‑p, Kit (rat): Y722‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase WT PTPRA
SCF decrease PTPRA -/-
SU6656 SCF inhibit treatment-induced increase
SU6656 SCF augment treatment-induced decrease
SCF increase PTPRA WT
SCF SCF no effect upon treatment-induced increase PTPRA-/-restored PTPRA

Y508-p - LYN (mouse)
Modsite: YtATEGQyQQQP___ SwissProt Entrez-Gene
Orthologous residues
LYN (human): Y508‑p, LYN iso2 (human): Y487‑p, LYN (mouse): Y508‑p, LYN iso2 (mouse): Y487‑p, LYN (rat): Y508‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF increase PTPRA -/-

T180-p - P38A (mouse)
Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

Y182-p - P38A (mouse)
Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

T423-p - PAK1 (mouse)
Modsite: PEQSKRstMVGtPYW SwissProt Entrez-Gene
Orthologous residues
PAK1 (human): T423‑p, PAK1 (mouse): T423‑p, PAK1 (rat): T422‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-

T402-p - PAK2 (mouse)
Modsite: PEQSKRstMVGtPYW SwissProt Entrez-Gene
Orthologous residues
PAK2 (human): T402‑p, PAK2 (mouse): T402‑p, PAK2 (rat): T402‑p, PAK2 (rabbit): T402‑p, PAK2 (cow): T402‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  mast-bone marrow [PTPRA (mouse), homozygous knockout]
Cellular systems studied:  primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SCF increase PTPRA WT
SCF decrease PTPRA -/-