Curated Information
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Home > Curated Information Page > PubMed Id: 18703760
McConell GK, et al. (2008) Differential attenuation of AMPK activation during acute exercise following exercise training or AICAR treatment. J Appl Physiol 105, 1422-7 18703760
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S218-p - ACC2 (rat)
Modsite: PTMRPSMsGLHLVKR SwissProt Entrez-Gene
Orthologous residues
ACC2 (human): S222‑p, ACC2 (mouse): S212‑p, ACC2 (rat): S218‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acadesine increase soleus muscle
exercise increase soleus muscle
acadesine, exercise increase exercise after 10 days AICAR; soleus muscle
acadesine increase EDL muscle
exercise increase EDL muscle
acadesine, exercise no change compared to control exercise after 10 days AICAR; EDL muscle

T183-p - AMPKA1 (rat)
Modsite: SDGEFLRtsCGSPNY SwissProt Entrez-Gene
Orthologous residues
AMPKA1 (human): T183‑p, AMPKA1 iso2 (human): T198‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'muscle, skeletal'
Cellular systems studied:  primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
acadesine no change compared to control soleus muscle
exercise increase soleus muscle
acadesine, exercise increase exercise after 10 days AICAR; soleus muscle
acadesine increase EDL muscle
exercise no change compared to control EDL muscle
acadesine, exercise no change compared to control exercise after 10 days AICAR; EDL muscle