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Home > Curated Information Page > PubMed Id: 15601748
Wahab NA, Weston BS, Mason RM (2005) Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA. J Am Soc Nephrol 16, 340-51 15601748
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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T308-p - Akt1 (human)
Modsite: KDGATMKtFCGTPEY SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T308‑p, Akt1 iso2 (human): T246‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

S473-p - Akt1 (human)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

T71-p - ATF-2 (human)
Modsite: IVADQTPtPTRFLKN SwissProt Entrez-Gene
Orthologous residues
ATF‑2 (human): T71‑p, ATF‑2 (mouse): T53‑p, ATF‑2 (rat): T53‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

T286-p - CAMK2A (human)
Modsite: SCMHRQEtVDCLKKF SwissProt Entrez-Gene
Orthologous residues
CAMK2A (human): T286‑p, CAMK2A iso2 (human): T286‑p, CAMK2A (mouse): T286‑p, CAMK2A iso2 (mouse): , CAMK2A (rat): T286‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

T202-p - ERK1 (human)
Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): T202‑p, ERK1 iso2 (human): T202‑p, ERK1 iso3 (human): T202‑p, ERK1 (mouse): T203‑p, ERK1 (rat): T203‑p, ERK1 (hamster): T192‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

Y204-p - ERK1 (human)
Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene
Orthologous residues
ERK1 (human): Y204‑p, ERK1 iso2 (human): Y204‑p, ERK1 iso3 (human): Y204‑p, ERK1 (mouse): Y205‑p, ERK1 (rat): Y205‑p, ERK1 (hamster): Y194‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

T185-p - ERK2 (human)
Modsite: HDHTGFLtEYVATRW SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p, ERK2 (cow): T185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

Y187-p - ERK2 (human)
Modsite: HTGFLTEyVATRWYR SwissProt Entrez-Gene
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p, ERK2 (cow): Y187‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

T219-p - ERK5 (human)
Modsite: AEHQYFMtEYVATRW SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): T219‑p, ERK5 iso2 (human): T80‑p, ERK5 (mouse): T219‑p, ERK5 (rat): T219‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase

Y221-p - ERK5 (human)
Modsite: HQYFMTEyVATRWYR SwissProt Entrez-Gene
Orthologous residues
ERK5 (human): Y221‑p, ERK5 iso2 (human): Y82‑p, ERK5 (mouse): Y221‑p, ERK5 (rat): Y221‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase

T183-p - JNK1 (human)
Modsite: AGTSFMMtPYVVTRY SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): T183‑p, JNK1 iso2 (human): T183‑p, JNK1 iso3 (human): T183‑p, JNK1 (mouse): T183‑p, JNK1 (rat): T183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

Y185-p - JNK1 (human)
Modsite: TSFMMTPyVVTRYYR SwissProt Entrez-Gene
Orthologous residues
JNK1 (human): Y185‑p, JNK1 iso2 (human): Y185‑p, JNK1 iso3 (human): Y185‑p, JNK1 (mouse): Y185‑p, JNK1 (rat): Y185‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
CTGF increase
K252a CTGF inhibit treatment-induced increase

S218-p - MEK1 (human)
Modsite: VSGQLIDsMANSFVG SwissProt Entrez-Gene
Orthologous residues
MEK1 (human): S218‑p, MEK1 iso2 (human): S192‑p, MEK1 (mouse): S218‑p, MEK1 (rat): S218‑p, MEK1 (rabbit): S218‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

S222-p - MEK2 (human)
Modsite: VSGQLIDsMANSFVG SwissProt Entrez-Gene
Orthologous residues
MEK2 (human): S222‑p, MEK2 (mouse): S222‑p, MEK2 (rat): S222‑p, MEK2 (chicken): S220‑p, MEK2 (cow): S222‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

T261-p - MKK4 (human)
Modsite: LVDSIAKtRDAGCRP SwissProt Entrez-Gene
Orthologous residues
MKK4 (human): T261‑p, MKK4 iso2 (human): T272‑p, MKK4 (mouse): T259‑p, MKK4 (rat): T259‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

T180-p - P38A (human)
Modsite: RHTDDEMtGYVATRW SwissProt Entrez-Gene
Orthologous residues
P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase

Y182-p - P38A (human)
Modsite: TDDEMTGyVATRWYR SwissProt Entrez-Gene
Orthologous residues
P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase

S380-p - p90RSK (human)
Modsite: HQLFRGFsFVATGLM SwissProt Entrez-Gene
Orthologous residues
p90RSK (human): S380‑p, p90RSK iso2 (human): S389‑p, p90RSK (mouse): S369‑p, p90RSK iso3 (mouse): , p90RSK (rat): S380‑p, p90RSK (chicken): S398‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase

Y496-p - TrkA (human)
Modsite: HIIENPQyFSDACVH SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y496‑p, TrkA iso2 (human): Y490‑p, TrkA (mouse): Y499‑p, TrkA (rat): Y499‑p, TrkA iso2 (rat): Y493‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, receptor internalization, altered

Y680-p - TrkA (human)
Modsite: RDIYSTDyYRVGGRT SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y680‑p, TrkA iso2 (human): Y674‑p, TrkA (mouse): Y683‑p, TrkA (rat): Y683‑p, TrkA iso2 (rat): Y677‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase
CTGF increase
K252a CTGF inhibit treatment-induced increase
NGF increase
K252a CTGF inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, receptor internalization, altered

Y681-p - TrkA (human)
Modsite: DIYSTDYyRVGGRTM SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y681‑p, TrkA iso2 (human): Y675‑p, TrkA (mouse): Y684‑p, TrkA (rat): Y684‑p, TrkA iso2 (rat): Y678‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CTGF increase
K252a CTGF inhibit treatment-induced increase
CTGF increase
K252a CTGF inhibit treatment-induced increase
NGF increase
K252a CTGF inhibit treatment-induced increase
Downstream Regulation
Effect of modification (function):  enzymatic activity, induced, receptor internalization, altered