Curated Information
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Home > Curated Information Page > PubMed Id: 19075013
Zuckerman V, et al. (2009) c-Abl phosphorylates Hdmx and regulates its interaction with p53. J Biol Chem 284, 4031-9 19075013
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y55-p - MDM4 (human)
Modsite: TVKEVMHyLGQYIMV SwissProt Entrez-Gene
Orthologous residues
MDM4 (human): Y55‑p, MDM4 iso5 (human): Y55‑p, MDM4 (mouse): Y55‑p, MDM4 (rat): Y56‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) transfection of inactive enzyme, transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
adriamycin increase

Y99-p - MDM4 (human)
Modsite: VkDPsPLyDMLRKNL SwissProt Entrez-Gene
Orthologous residues
MDM4 (human): Y99‑p, MDM4 iso5 (human): Y99‑p, MDM4 (mouse): Y99‑p, MDM4 (rat): Y100‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) transfection of inactive enzyme, transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate, H2O2 increase
adriamycin increase
Downstream Regulation
Effect of modification (function):  molecular association, regulation, phosphorylation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
p53 (human) Disrupts co-immunoprecipitation
Comments:  affects Y55 phosphorylation

S342-p - MDM4 (human)
Modsite: SkLTHSLsTSDITAI SwissProt Entrez-Gene
Orthologous residues
MDM4 (human): S342‑p, MDM4 iso5 (human): S292‑p, MDM4 (mouse): S341‑p, MDM4 (rat): S342‑p

S367-p - MDM4 (human)
Modsite: PDCRRtIsAPVVRPk SwissProt Entrez-Gene
Orthologous residues
MDM4 (human): S367‑p, MDM4 iso5 (human): S317‑p, MDM4 (mouse): S367‑p, MDM4 (rat): S368‑p