Curated Information
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Home > Curated Information Page > PubMed Id: 27572314
Wegwitz F, et al. (2016) CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo. Oncotarget 7, 63730-63746 27572314
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S33-p - CTNNB1 (mouse)
Modsite: QQQsYLDsGIHsGAT SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  mouse
Comments:  G-2 cells derived from primary mammary adenocarcinomas grown in WAP-T mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CEACAM1 (mouse) increase
NSC-87877 decrease

S37-p - CTNNB1 (mouse)
Modsite: YLDsGIHsGATtTAP SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  mouse
Comments:  G-2 cells derived from primary mammary adenocarcinomas grown in WAP-T mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CEACAM1 (mouse) increase
NSC-87877 decrease

T41-p - CTNNB1 (mouse)
Modsite: GIHsGATtTAPsLSG SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  mouse
Comments:  G-2 cells derived from primary mammary adenocarcinomas grown in WAP-T mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CEACAM1 (mouse) increase
NSC-87877 decrease

Y86-p - CTNNB1 (mouse)
Modsite: VADIDGQyAMTRAQR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): Y86‑p, CTNNB1 (mouse): Y86‑p, CTNNB1 (rat): Y86‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Cellular systems studied:  cell lines
Species studied:  mouse
Comments:  G-2 cells derived from primary mammary adenocarcinomas grown in WAP-T mice
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CEACAM1 (mouse) decrease Ceacam1 shRNA increase
NSC-87877 increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  transcription, induced
Comments:  translocation to nucleus