Pangou E, et al. (2016) HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia. J Cell Sci 129, 4213-4226 27686097

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S383-p - HIF2A (human) ▲

Modsite: SSGKGAVsEkSNFLF SwissProt Entrez-Gene Orthologous residues HIF2A (human): S383‑p, HIF2A (mouse): T383‑p, HIF2A (rat): S383‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  liver cancer, hepatocellular carcinoma Relevant cell lines - cell types - tissues:  HepG2 (hepatic), Huh7 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK1D (human) Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  transcription, induced Comments:  EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A

T528-p - HIF2A (human) ▲

Modsite: FNELDLEtLAPYIPM SwissProt Entrez-Gene Orthologous residues HIF2A (human): T528‑p, HIF2A (mouse): T527‑p, HIF2A (rat): T527‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry (in vitro), mutation of modification site Disease tissue studied:  liver cancer, hepatocellular carcinoma Relevant cell lines - cell types - tissues:  HepG2 (hepatic), Huh7 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE CK1D (human) Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  transcription, induced Comments:  EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A