Curated Information
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Home > Curated Information Page > PubMed Id: 27707973
Wang XF, et al. (2016) T394A Mutation at the μ Opioid Receptor Blocks Opioid Tolerance and Increases Vulnerability to Heroin Self-Administration in Mice. J Neurosci 36, 10392-10403 27707973
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T394-p - MOR-1 (mouse)
Modsite: LENLEAEtAPLP___ SwissProt Entrez-Gene
Orthologous residues
MOR‑1 (human): T396‑p, MOR‑1 iso5 (human): M395‑p, MOR‑1 (mouse): T394‑p, MOR‑1 (rat): T394‑p
Characterization
Methods used to characterize site in vivo mutation of modification site
Relevant cell lines - cell types - tissues:  spinal cord
Cellular systems studied:  tissue
Species studied:  mouse
Comments:  lumbar segments
Downstream Regulation
Effect of modification (function):  receptor desensitization, induced, receptor internalization, induced
Comments:  tolerance in both opioid analgesia and opioid reward