Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 27662363
Yu C, Kim BS, Kim E (2016) FAF1 mediates regulated necrosis through PARP1 activation upon oxidative stress leading to dopaminergic neurodegeneration. Cell Death Differ 23, 1873-1885 27662363
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

S289-p - FAF1 (human)
Modsite: ITDVHMVsDsDGDDF SwissProt Entrez-Gene
Orthologous residues
FAF1 (human): S289‑p, FAF1 iso2 (human): , FAF1 (mouse): S288‑p, FAF1 (rat): S288‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  MEF (fibroblast), SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  nuclear localization

S291-p - FAF1 (human)
Modsite: DVHMVsDsDGDDFED SwissProt Entrez-Gene
Orthologous residues
FAF1 (human): S291‑p, FAF1 iso2 (human): , FAF1 (mouse): S290‑p, FAF1 (rat): S290‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  neuroblastoma
Relevant cell lines - cell types - tissues:  MEF (fibroblast), SH-SY5Y (neural crest)
Cellular systems studied:  cell lines
Species studied:  mouse
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  nuclear localization