Dai X, et al. (2016) Phosphorylation of CHOP (C/EBP Homologous Protein) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res 119, 1089-1100 27650555

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S30-p - DDIT3 (human) ▲

Modsite: EDLQEVLssDENGGT SwissProt Entrez-Gene Orthologous residues DDIT3 (human): S30‑p, DDIT3 (mouse): S30‑p, DDIT3 (rat): S30‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  macrophage-bone marrow, RAW 264.7 (macrophage) Cellular systems studied:  cell lines, primary cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE AMPKA1 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE AMPKA1 (human) genetic knockout/knockin of upstream enzyme, modification site within consensus motif, co-immunoprecipitation, pharmacological activator of upstream enzyme, phospho-antibody, microscopy-colocalization Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes acadesine increase A79662 increase compound_C decrease Downstream Regulation Effect of modification (function):  protein degradation, ubiquitination