Lerner-Marmarosh N, et al. (2005) Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc Natl Acad Sci U S A 102, 7109-14 15870194

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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Y72-p - BVR (human) ▲
Modsite: SQEVEVAyICSESSS SwissProt Entrez-Gene Orthologous residues BVR (human): Y72‑p, BVR (mouse): Y71‑p, BVR (rat): Y71‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE BVR (human)

Y83-p - BVR (human) ▲
Modsite: ESSSHEDyIRQFLNA SwissProt Entrez-Gene Orthologous residues BVR (human): Y83‑p, BVR (mouse): Y82‑p, BVR (rat): Y82‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE BVR (human)

Y198-p - BVR (human) ▲

Modsite: EERKEDQyMKMtVCL SwissProt Entrez-Gene Orthologous residues BVR (human): Y198‑p, BVR (mouse): Y197‑p, BVR (rat): Y197‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293-A (epithelial) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE INSR (human) Downstream Regulation Effect of modification (function):  enzymatic activity, induced Comments:  phosphorylation enhances BVR's antagonism of insulin-stimulated glucose uptake.

Y228-p - BVR (human) ▲
Modsite: PGLKRNRyLsFHFks SwissProt Entrez-Gene Orthologous residues BVR (human): Y228‑p, BVR (mouse): H227‑p, BVR (rat): Y227‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE INSR (human)

Y291-p - BVR (human) ▲
Modsite: LAEEIQkyCCSRK__ SwissProt Entrez-Gene Orthologous residues BVR (human): Y291‑p, BVR (mouse): L290‑p, BVR (rat): L290‑p Characterization Enzymes shown to modify site in vitro:  Type Enzyme KINASE INSR (human)