Curated Information
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Home > Curated Information Page > PubMed Id: 21276944
Dhayalan A, Kudithipudi S, Rathert P, Jeltsch A (2011) Specificity analysis-based identification of new methylation targets of the SET7/9 protein lysine methyltransferase. Chem Biol 18, 111-20 21276944
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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K604-me - AKAP6 (human)
Modsite: LLSKHKSkKGQASSP SwissProt Entrez-Gene
Orthologous residues
AKAP6 (human): K604‑me, AKAP6 (mouse): Q601‑me, AKAP6 (rat): Q603‑me

K414-me - CENPC1 (human)
Modsite: AEKPSRSkRTIKQKQ SwissProt Entrez-Gene
Orthologous residues
CENPC1 (human): K414‑me, CENPC1 (mouse): E380‑me, CENPC1 (rat): K394‑me
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme

K73-me - CUL1 (human)
Modsite: GVPPsKSkkGQtPGG SwissProt Entrez-Gene
Orthologous residues
CUL1 (human): K73‑me, CUL1 (mouse): K73‑me

K142-me - DNMT1 (human)
Modsite: PRtPRRsksDGEAkP SwissProt Entrez-Gene
Orthologous residues
DNMT1 (human): K142‑me, DNMT1 iso2 (human): K142‑me, DNMT1 (mouse): K139‑me, DNMT1 (rat): K139‑me

K302-me - ER-alpha (human)
Modsite: PLMIkRSkkNsLALS SwissProt Entrez-Gene
Orthologous residues
ER‑alpha (human): K302‑me, ER‑alpha (mouse): K306‑me, ER‑alpha (rat): K307‑me

K4-me - H3 (human)
Modsite: ____ArtkQtArkst SwissProt Entrez-Gene
Orthologous residues
H3 (human): K4‑me, H3 (mouse): K4‑me, H3 iso2 (mouse): K4‑me, H3 iso3 (mouse): K4‑me, H3 (rat): K4‑me, H3 iso3 (rat): K4‑me, H3 (pig): K4‑me, H3 (chicken): K4‑me, H3 (cow): K4‑me

K126-me - IRF1 (human)
Modsite: QRKERKSkSSRDAKS SwissProt Entrez-Gene
Orthologous residues
IRF1 (human): K126‑me, IRF1 (mouse): K126‑me, IRF1 (rat): K126‑me
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme

K347-me - MECP2 (human)
Modsite: KSPGRKSkEsSPKGR SwissProt Entrez-Gene
Orthologous residues
MECP2 (human): K347‑me, MECP2 iso2 (human): K359‑me, MECP2 (mouse): K347‑me, MECP2 iso2 (mouse): K364‑me, MECP2 (rat): K347‑me
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme

K1006-me - MED1 (human)
Modsite: PsNDGkSkDKPPkRK SwissProt Entrez-Gene
Orthologous residues
MED1 (human): K1006‑me, MED1 (mouse): K1006‑me, MED1 (rat): K991‑me

K37-me - NFkB-p65 (human)
Modsite: RGMRFRYkCEGRsAG SwissProt Entrez-Gene
Orthologous residues
NFkB‑p65 (human): K37‑me, NFkB‑p65 (mouse): K37‑me, NFkB‑p65 (rat): K37‑me

K372-me - p53 (human)
Modsite: HsSHLkskkGQstsR SwissProt Entrez-Gene
Orthologous residues
p53 (human): K372‑me, p53 iso2 (human): , p53 iso4 (human): K333‑me, p53 (mouse): K369‑me, p53 iso2 (mouse): , p53 (rat): K370‑me, p53 (rabbit): K370‑me, p53 (green monkey): K372‑me

K2076-me - SHARP (human)
Modsite: PEKNSKSkRGRSRNS SwissProt Entrez-Gene
Orthologous residues
SHARP (human): K2076‑me, SHARP (mouse): K2087‑me, SHARP (rat): K2062‑me
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme

K2076-m2 - SHARP (human)
Modsite: PEKNSKSkRGRSRNS SwissProt Entrez-Gene
Orthologous residues
SHARP (human): K2076‑m2, SHARP (mouse): K2087‑m2, SHARP (rat): K2062‑m2
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme

K189-me - TAF10 (human)
Modsite: GSSRskSkDRKYTLT SwissProt Entrez-Gene
Orthologous residues
TAF10 (human): K189‑me, TAF10 (mouse): K189‑me, TAF10 (rat): K189‑me

K708-me - TTK (human)
Modsite: SRENGKSkSKISPKS SwissProt Entrez-Gene
Orthologous residues
TTK (human): K708‑me, TTK iso2 (human): K707‑me, TTK (mouse): R707‑me, TTK iso2 (mouse): R681‑me, TTK (rat): K686‑me, TTK (frog): R729‑me

K300-me - ZDHHC8 (human)
Modsite: GLGRSKSkGSLDRLD SwissProt Entrez-Gene
Orthologous residues
ZDHHC8 (human): K300‑me, ZDHHC8 iso3 (human): K300‑me, ZDHHC8 (mouse): K298‑me, ZDHHC8 (rat): K298‑me
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  293 (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
METHYLTRANSFERASE SETD7 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
METHYLTRANSFERASE SETD7 (human) transfection of wild-type enzyme