Curated Information
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Home > Curated Information Page > PubMed Id: 27625374
Suryo Rahmanto A, et al. (2016) FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. EMBO J 35, 2192-2212 27625374
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T236-p - SOX9 (human)
Modsite: GQSQGPPtPPtTPKT SwissProt Entrez-Gene
Orthologous residues
SOX9 (human): T236‑p, SOX9 (mouse): T236‑p, SOX9 (rat): T236‑p, SOX9 (chicken): T236‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Disease tissue studied:  brain cancer, medulloblastoma
Relevant cell lines - cell types - tissues:  Daoy
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation, protein degradation, ubiquitination
Effect of modification (process):  transcription, altered
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
FBXW7 (human) Induces in vitro, pull-down assay