Curated Information
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Home > Curated Information Page > PubMed Id: 27528614
Sosna J, et al. (2016) Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells. Mol Cell Biol 36, 2626-44 27528614
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T75-p - ATG5 (human)
Modsite: IWFEYEGtPLKWHyP SwissProt Entrez-Gene
Orthologous residues
ATG5 (human): T75‑p, ATG5 (mouse): T75‑p, ATG5 (rat): T75‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma, leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  HT-29 (intestinal), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human

S32-p - IkB-alpha (human)
Modsite: LLDDRHDsGLDsMkD SwissProt Entrez-Gene
Orthologous residues
IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma, leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  HT-29 (intestinal), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TRAIL decrease
Z-VAD-FMK TRAIL increase
TNF increase
Z-VAD-FMK TNF decrease

S536-p - NFkB-p65 (human)
Modsite: sGDEDFSsIADMDFS SwissProt Entrez-Gene
Orthologous residues
NFkB‑p65 (human): S536‑p, NFkB‑p65 (mouse): S534‑p, NFkB‑p65 (rat): S535‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  colorectal cancer, colorectal carcinoma, leukemia, T cell leukemia
Relevant cell lines - cell types - tissues:  HT-29 (intestinal), Jurkat (T lymphocyte)
Cellular systems studied:  cell lines
Species studied:  human