Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 27521268
Ban T, et al. (2016) Lyn Kinase Suppresses the Transcriptional Activity of IRF5 in the TLR-MyD88 Pathway to Restrain the Development of Autoimmunity. Immunity 45, 319-32 27521268
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

Y313-p - IRF5 (human)
Modsite: PSDkQRFyTNQLLDV SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): Y313‑p, IRF5 iso2 (human): Y329‑p, IRF5 (mouse): Y312‑p, IRF5 (rat): Y312‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LYN (human) phosphopeptide analysis, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LYN (human) Induces transcription, inhibited co-immunoprecipitation
Comments:  inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes

Y335-p - IRF5 (human)
Modsite: QLQGQDLyAIRLCQC SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): Y335‑p, IRF5 iso2 (human): Y351‑p, IRF5 (mouse): Y334‑p, IRF5 (rat): Y334‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LYN (human) phosphopeptide analysis, transfection of wild-type enzyme
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LYN (human) Induces transcription, inhibited co-immunoprecipitation
Comments:  inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes

K411-ub - IRF5 (human)
Modsite: PDRKPREkkLITVQV SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): K411‑ub, IRF5 iso2 (human): K427‑ub, IRF5 (mouse): K410‑ub, IRF5 (rat): K410‑ub
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LYN (human) Induces transcription, inhibited co-immunoprecipitation
Comments:  inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes

K412-ub - IRF5 (human)
Modsite: DRKPREkkLITVQVV SwissProt Entrez-Gene
Orthologous residues
IRF5 (human): K412‑ub, IRF5 iso2 (human): K428‑ub, IRF5 (mouse): K411‑ub, IRF5 (rat): K411‑ub
Downstream Regulation
Effect of modification (function):  molecular association, regulation, ubiquitination
Effect of modification (process):  transcription, inhibited
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
LYN (human) Induces transcription, inhibited co-immunoprecipitation
Comments:  inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes