Curated Information
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Home > Curated Information Page > PubMed Id: 27472223
Zigler JS, et al. (2016) A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems. PLoS One 11, e0160447 27472223
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S333-p - BCKDH E1-alpha (rat)
Modsite: TYRIGHHstsDDSSA SwissProt Entrez-Gene
Orthologous residues
BCKDH E1‑alpha (human): S337‑p, BCKDH E1‑alpha (mouse): S334‑p, BCKDH E1‑alpha (rat): S333‑p, BCKDH E1‑alpha (pig): S339‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  brain
Cellular systems studied:  tissue
Species studied:  rat
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE BCKDK (rat) phospho-antibody, genetic knockout/knockin of upstream enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
decrease BCKDK frogleg mutation
Downstream Regulation
Effect of modification (function):  enzymatic activity, inhibited
Effect of modification (process):  cell growth, induced
Comments:  inhibited catabolism of the branched-chain amino acids, decrease phosphorylation frogleg phenotype