Zigler JS, et al. (2016) A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems. PLoS One 11, e0160447 27472223

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S333-p - BCKDH E1-alpha (rat) ▲

Modsite: TYRIGHHstsDDSSA SwissProt Entrez-Gene Orthologous residues BCKDH E1‑alpha (human): S337‑p, BCKDH E1‑alpha (mouse): S334‑p, BCKDH E1‑alpha (rat): S333‑p, BCKDH E1‑alpha (pig): S339‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  brain Cellular systems studied:  tissue Species studied:  rat Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE BCKDK (rat) phospho-antibody, genetic knockout/knockin of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes decrease BCKDK frogleg mutation Downstream Regulation Effect of modification (function):  enzymatic activity, inhibited Effect of modification (process):  cell growth, induced Comments:  inhibited catabolism of the branched-chain amino acids, decrease phosphorylation frogleg phenotype