Curated Information
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Home > Curated Information Page > PubMed Id: 14662744
Marsh HN, et al. (2003) SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol 163, 999-1010 14662744
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y496-p - TrkA (human)
Modsite: HIIENPQyFSDACVH SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y496‑p, TrkA iso2 (human): Y490‑p, TrkA (mouse): Y499‑p, TrkA (rat): Y499‑p, TrkA iso2 (rat): Y493‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

Y680-p - TrkA (human)
Modsite: RDIySTDyyRVGGRT SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y680‑p, TrkA iso2 (human): Y674‑p, TrkA (mouse): Y683‑p, TrkA (rat): Y683‑p, TrkA iso2 (rat): Y677‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

Y681-p - TrkA (human)
Modsite: DIySTDyyRVGGRTM SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y681‑p, TrkA iso2 (human): Y675‑p, TrkA (mouse): Y684‑p, TrkA (rat): Y684‑p, TrkA iso2 (rat): Y678‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

S473-p - Akt1 (rat)
Modsite: RPHFPQFsYSASGTA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S473‑p, Akt1 iso2 (human): S411‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase

Y683-p - TrkA (rat)
Modsite: RDIySTDyyRVGGRT SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y680‑p, TrkA iso2 (human): Y674‑p, TrkA (mouse): Y683‑p, TrkA (rat): Y683‑p, TrkA iso2 (rat): Y677‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) co-immunoprecipitation, transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase

Y684-p - TrkA (rat)
Modsite: DIySTDyyRVGGRTM SwissProt Entrez-Gene
Orthologous residues
TrkA (human): Y681‑p, TrkA iso2 (human): Y675‑p, TrkA (mouse): Y684‑p, TrkA (rat): Y684‑p, TrkA iso2 (rat): Y678‑p
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) co-immunoprecipitation, transfection of wild-type enzyme
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase