Curated Information
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Home > Curated Information Page > PubMed Id: 27366950
Picco V, et al. (2016) ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2. Oncotarget 7, 46615-46627 27366950
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S365-p - TRF2 (human)
Modsite: PTQALPAsPALKNKR SwissProt Entrez-Gene
Orthologous residues
TRF2 (human): S365‑p, TRF2 (mouse): S367‑p, TRF2 (rat): S321‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
Disease tissue studied:  melanoma skin cancer
Relevant cell lines - cell types - tissues:  A375 (melanocyte), BJ (fibroblast)
Cellular systems studied:  cell lines
Species studied:  human
Enzymes shown to modify site in vitro
Type Enzyme
KINASE ERK2 (human)
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) phospho-antibody, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme
Downstream Regulation
Effect of modification (function):  protein stabilization
Effect of modification (process):  cell growth, induced