Curated Information
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Home > Curated Information Page > PubMed Id: 27197201
Li Y, et al. (2016) p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res 76, 4002-11 27197201
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S10-p - p27Kip1 (human)
Modsite: NVRVSNGsPsLErMD SwissProt Entrez-Gene
Orthologous residues
p27Kip1 (human): S10‑p, p27Kip1 (mouse): S10‑p, p27Kip1 (rat): S10‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, osteosarcoma
Relevant cell lines - cell types - tissues:  Dunn (osteoblast), K7M2 (osteoblast), Saos-2 (bone cell)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  cell motility, induced
Comments:  migration and invasion, cytoplasmic localization

T157-p - p27Kip1 (human)
Modsite: GIRkrPAtDDSSTQN SwissProt Entrez-Gene
Orthologous residues
p27Kip1 (human): T157‑p, p27Kip1 (mouse): A157‑p, p27Kip1 (rat): A157‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, osteosarcoma
Relevant cell lines - cell types - tissues:  Dunn (osteoblast), K7M2 (osteoblast), Saos-2 (bone cell)
Cellular systems studied:  cell lines
Species studied:  human, mouse

T198-p - p27Kip1 (human)
Modsite: PGLRRRQt_______ SwissProt Entrez-Gene
Orthologous residues
p27Kip1 (human): T198‑p, p27Kip1 (mouse): T197‑p, p27Kip1 (rat): T197‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, western blotting
Disease tissue studied:  bone cancer, osteosarcoma
Relevant cell lines - cell types - tissues:  Dunn (osteoblast), K7M2 (osteoblast), Saos-2 (bone cell)
Cellular systems studied:  cell lines
Species studied:  human, mouse
Downstream Regulation
Effect of modification (function):  intracellular localization
Comments:  migration and invasion, cytoplasmic localization