Park JW, Zhao L, Willingham MC, Cheng SY (2017) Loss of tyrosine phosphorylation at Y406 abrogates the tumor suppressor functions of the thyroid hormone receptor β. Mol Carcinog 56, 489-498 27254276

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S32-p - IkB-alpha (human) ▲

Modsite: LLDDRHDsGLDsMkD SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  PC CL 3 (thyroid cell) [TR-beta1 (human), transfection] Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TR-beta1 (human) decrease Y406F mutant

S36-p - IkB-alpha (human) ▲

Modsite: RHDsGLDsMkDEEyE SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S36‑p, IkB‑alpha (mouse): S36‑p, IkB‑alpha (rat): S36‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  PC CL 3 (thyroid cell) [TR-beta1 (human), transfection] Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TR-beta1 (human) decrease Y406F mutant

S780-p - Rb (human) ▲

Modsite: strPPtLsPIPHIPr SwissProt Entrez-Gene Orthologous residues Rb (human): S780‑p, Rb (mouse): S773‑p, Rb (rat): S772‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  PC CL 3 (thyroid cell) [TR-beta1 (human), transfection] Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TR-beta1 (human) increase Y406F mutant

Y419-p - Src (human) ▲

Modsite: RLIEDNEytARQGAk SwissProt Entrez-Gene Orthologous residues Src (human): Y419‑p, Src iso2 (human): Y425‑p, Src (mouse): Y418‑p, Src iso1 (mouse): Y424‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  PC CL 3 (thyroid cell) [TR-beta1 (human), transfection] Cellular systems studied:  cell lines Species studied:  rat Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes TR-beta1 (human) increase Y406F mutant

Y406-p - TR-beta1 (human) ▲

Modsite: FLLAFEHyINYRKHH SwissProt Entrez-Gene Orthologous residues TR‑beta1 (human): Y406‑p, TR‑beta1 (mouse): Y406‑p, TR‑beta1 iso2 (mouse): Y420‑p, TR‑beta1 (rat): Y406‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  PC CL 3 (thyroid cell) [TR-beta1 (human), transfection] Cellular systems studied:  cell lines Species studied:  rat Downstream Regulation Effect of modification (function):  protein degradation Effect of modification (process):  carcinogenesis, inhibited, cell growth, inhibited Comments:  TR-beta1Y406F loses tumor supressor function