Kawakami Y, et al. (2003) A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A 100, 9470-5 12881490

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S657-p - PKCA (mouse) ▲

Modsite: QsDFEGFsyVNPQFV SwissProt Entrez-Gene Orthologous residues PKCA (human): S657‑p, PKCA (mouse): S657‑p, PKCA (rat): S657‑p, PKCA (cow): S657‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  mast-bone marrow, MCP-5 (mast) Cellular systems studied:  cell lines, primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCA (mouse)

Y658-p - PKCA (mouse) ▲

Modsite: sDFEGFsyVNPQFVH SwissProt Entrez-Gene Orthologous residues PKCA (human): Y658‑p, PKCA (mouse): Y658‑p, PKCA (rat): Y658‑p, PKCA (cow): Y658‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  mast-bone marrow, MCP-5 (mast) Cellular systems studied:  cell lines, primary cultured cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE Syk (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Syk (mouse) Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays GRB2 (mouse) Induces co-immunoprecipitation

S661-p - PKCB (mouse) ▲

Modsite: QNEFAGFsyTNPEFV SwissProt Entrez-Gene Orthologous residues PKCB (human): S661‑p, PKCB iso2 (human): ‑, PKCB (mouse): S661‑p, PKCB iso2 (mouse): ‑, PKCB (rat): S661‑p, PKCB iso2 (rat): ‑, PKCB (cow): ‑ Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  mast-bone marrow, MCP-5 (mast) Cellular systems studied:  cell lines, primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCB (mouse)

Y662-p - PKCB (mouse) ▲

Modsite: NEFAGFsyTNPEFVI SwissProt Entrez-Gene Orthologous residues PKCB (human): Y662‑p, PKCB iso2 (human): ‑, PKCB (mouse): Y662‑p, PKCB iso2 (mouse): ‑, PKCB (rat): Y662‑p, PKCB iso2 (rat): ‑, PKCB (cow): ‑ Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  mast-bone marrow, MCP-5 (mast) Cellular systems studied:  cell lines, primary cultured cells Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE Syk (mouse) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE Syk (mouse) Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes antigenic stimulation increase Downstream Regulation Effect of modification (function):  molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays GRB2 (mouse) Induces co-immunoprecipitation

S660-p - PKCB iso2 (mouse) ▲

Modsite: QsEFEGFsFVNsEFL SwissProt Entrez-Gene Orthologous residues PKCB (human): ‑, PKCB iso2 (human): S660‑p, PKCB (mouse): ‑, PKCB iso2 (mouse): S660‑p, PKCB (rat): ‑, PKCB iso2 (rat): S660‑p, PKCB (cow): S660‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  mast-bone marrow, MCP-5 (mast) Cellular systems studied:  cell lines, primary cultured cells Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCB (mouse)