Curated Information
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Home > Curated Information Page > PubMed Id: 27303922
Guo J, et al. (2016) Inhibiting cytoplasmic accumulation of HuR synergizes genotoxic agents in urothelial carcinoma of the bladder. Oncotarget 7, 45249-45262 27303922
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y15-p - CDK1 (human)
Modsite: EkIGEGtyGVVykGR SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): Y15‑p, CDK1 iso2 (human): Y15‑p, CDK1 (mouse): Y15‑p, CDK1 (rat): Y15‑p, CDK1 (chicken): Y15‑p, CDK1 (fruit fly): Y15‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
adriamycin increase
pyrvinium pamoate adriamycin decrease

T161-p - CDK1 (human)
Modsite: GIPIRVytHEVVTLW SwissProt Entrez-Gene
Orthologous residues
CDK1 (human): T161‑p, CDK1 iso2 (human): , CDK1 (mouse): T161‑p, CDK1 (rat): T161‑p, CDK1 (chicken): T161‑p, CDK1 (fruit fly): T161‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
adriamycin pyrvinium pamoate increase
pyrvinium pamoate augment treatment-induced increase

S345-p - Chk1 (human)
Modsite: LVQGIsFsQPtCPDH SwissProt Entrez-Gene
Orthologous residues
Chk1 (human): S345‑p, Chk1 (mouse): S345‑p, Chk1 (rat): S345‑p, Chk1 (chicken): S345‑p
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
adriamycin increase
pyrvinium pamoate adriamycin decrease

S202-p - HuR (human)
Modsite: LLsQLyHsPArrFGG SwissProt Entrez-Gene
Orthologous residues
HuR (human): S202‑p, HuR iso2 (human): S229‑p, HuR (mouse): S202‑p, HuR (rat): S202‑p
Downstream Regulation
Effect of modification (function):  intracellular localization

K22-ac - KPNA2 (human)
Modsite: HRFKNkGkDsTEMRR SwissProt Entrez-Gene
Orthologous residues
KPNA2 (human): K22‑ac, KPNA2 (mouse): K22‑ac, KPNA2 (rat): K22‑ac

S105-p - KPNA2 (human)
Modsite: QAARkLLsREkQPPI SwissProt Entrez-Gene
Orthologous residues
KPNA2 (human): S105‑p, KPNA2 (mouse): S105‑p, KPNA2 (rat): S105‑p