Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Curated Information Page > PubMed Id: 27298316
Savas Ü, et al. (2016) 20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR. J Biol Chem 291, 16904-19 27298316
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
Download

T53-p - NCCT (mouse)
Modsite: GSTLYMRtFGYNTID SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T55‑p, NCCT iso2 (human): T55‑p, NCCT iso3 (human): T55‑p, NCCT (mouse): T53‑p, NCCT (rat): T53‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase B-129/Sv-4A11 +/+ mice compared to wild-type (4A11-/-)

T58-p - NCCT (mouse)
Modsite: MRTFGYNtIDVVPAY SwissProt Entrez-Gene
Orthologous residues
NCCT (human): T60‑p, NCCT iso2 (human): T60‑p, NCCT iso3 (human): T60‑p, NCCT (mouse): T58‑p, NCCT (rat): T58‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase B-129/Sv-4A11 +/+ mice compared to wild-type (4A11-/-)
HET0016 decrease

S71-p - NCCT (mouse)
Modsite: AYEHYANsALPGEPR SwissProt Entrez-Gene
Orthologous residues
NCCT (human): S73‑p, NCCT iso2 (human): S73‑p, NCCT iso3 (human): S73‑p, NCCT (mouse): S71‑p, NCCT (rat): S71‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase B-129/Sv-4A11 +/+ mice compared to wild-type (4A11-/-)
HET0016 decrease

S89-p - NCCT (mouse)
Modsite: PTLADLHsFLKQEGS SwissProt Entrez-Gene
Orthologous residues
NCCT (human): S91‑p, NCCT iso2 (human): S91‑p, NCCT iso3 (human): S91‑p, NCCT (mouse): S89‑p, NCCT (rat): S89‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  kidney
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase B-129/Sv-4A11 +/+ mice compared to wild-type (4A11-/-)