Curated Information
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Home > Curated Information Page > PubMed Id: 27293189
Sannerud R, et al. (2016) Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell 166, 193-208 27293189
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S7-p - PSEN2 (human)
Modsite: _MLTFMAsDsEEEVC SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S7‑p, PSEN2 (mouse): S7‑p, PSEN2 (rat): S7‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  brain, MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)

S9-p - PSEN2 (human)
Modsite: LTFMAsDsEEEVCDE SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S9‑p, PSEN2 (mouse): S9‑p, PSEN2 (rat): S9‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  brain, MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)

S19-p - PSEN2 (human)
Modsite: EVCDERTsLMsAEsP SwissProt Entrez-Gene
Orthologous residues
PSEN2 (human): S19‑p, PSEN2 (mouse): S19‑p, PSEN2 (rat): S19‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, western blotting
Relevant cell lines - cell types - tissues:  brain, MEF (fibroblast)
Cellular systems studied:  cell lines
Species studied:  mouse, rat
Enzymes shown to modify site in vitro
Type Enzyme
KINASE AurA (human)
Downstream Regulation
Effect of modification (function):  molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
AP1G1 (human) Disrupts pull-down assay