Curated Information
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Home > Curated Information Page > PubMed Id: 27257073
Zhao Z, et al. (2016) Heat shock represses rRNA synthesis by inactivation of TIF-IA and lncRNA-dependent changes in nucleosome positioning. Nucleic Acids Res 44, 8144-52 27257073
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S170-p - TIF1A (human)
Modsite: KEGDVDVsDsDDEDD SwissProt Entrez-Gene
Orthologous residues
TIF1A (human): S170‑p, TIF1A (mouse): S168‑p
Characterization
Methods used to characterize site in vivo 2D analysis, phospho-antibody, phosphopeptide mapping, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (human) phosphopeptide analysis, phospho-motif antibody, 2D analysis
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease

S172-p - TIF1A (human)
Modsite: GDVDVsDsDDEDDNL SwissProt Entrez-Gene
Orthologous residues
TIF1A (human): S172‑p, TIF1A (mouse): S170‑p
Characterization
Methods used to characterize site in vivo 2D analysis, phospho-antibody, phosphopeptide mapping, western blotting
Relevant cell lines - cell types - tissues:  HEK293T (epithelial)
Cellular systems studied:  cell lines
Species studied:  human
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (human) phosphopeptide analysis, phospho-motif antibody, 2D analysis
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
heat_shock decrease