Illi B, et al. (2003) Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. Circ Res 93, 155-61 12805238

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S10-p - H3F3A (human) ▲

Modsite: tkQTARkstGGkAPR SwissProt Entrez-Gene Orthologous residues H3F3A (human): S10‑p, H3F3A (mouse): S10‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-vein Cellular systems studied:  primary cultured cells Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes fluid_shear_stress increase wortmannin fluid_shear_stress inhibit treatment-induced increase PD98059 fluid_shear_stress inhibit treatment-induced increase SB203580 fluid_shear_stress inhibit treatment-induced increase trichostatin_A fluid_shear_stress inhibit treatment-induced increase

S376-p - MSK1 (human) ▲

Modsite: EKLFQGysFVAPsIL SwissProt Entrez-Gene Orthologous residues MSK1 (human): S376‑p, MSK1 (mouse): S375‑p, MSK1 (rat): S329‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-vein Cellular systems studied:  primary cultured cells Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes fluid_shear_stress increase SB203580 fluid_shear_stress inhibit treatment-induced increase

S386-p - RSK2 (human) ▲

Modsite: HQLFRGFsFVAItsD SwissProt Entrez-Gene Orthologous residues RSK2 (human): S386‑p, RSK2 (mouse): S386‑p, RSK2 (rat): S386‑p, RSK2 (cow): S386‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  endothelial-vein Cellular systems studied:  primary cultured cells Species studied:  human Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes fluid_shear_stress increase SB203580 fluid_shear_stress inhibit treatment-induced increase