Curated Information
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Home > Curated Information Page > PubMed Id: 15851471
Nanda N, et al. (2005) Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem 280, 24680-9 15851471
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y925-p - PEAR1 (human)
Modsite: SLSSENPyATIRDLP SwissProt Entrez-Gene
Orthologous residues
PEAR1 (human): Y925‑p, PEAR1 (mouse): Y923‑p, PEAR1 (rat): Y922‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Comments:  aggregated platelets, induced by TRAP
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
thrombin increase
eptifibatide thrombin inhibit treatment-induced increase
TRAP increase
eptifibatide TRAP inhibit treatment-induced increase
collagen increase
eptifibatide collagen inhibit treatment-induced increase

S953-p - PEAR1 (human)
Modsite: MKGPPSGsPPRQPPQ SwissProt Entrez-Gene
Orthologous residues
PEAR1 (human): S953‑p, PEAR1 (mouse): S951‑p, PEAR1 (rat): S950‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Comments:  aggregated platelets, induced by TRAP

S1029-p - PEAR1 (human)
Modsite: PPVRHPPsPPLRRQD SwissProt Entrez-Gene
Orthologous residues
PEAR1 (human): S1029‑p, PEAR1 (mouse): S1026‑p, PEAR1 (rat): S1025‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  platelet-blood
Cellular systems studied:  primary cells
Species studied:  human
Comments:  aggregated platelets, induced by TRAP