Blee AM, Liu S, Wang L, Huang H (2016) BET bromodomain-mediated interaction between ERG and BRD4 promotes prostate cancer cell invasion. Oncotarget 7, 38319-38332 27223260

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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K89-ac - ERG (human) ▲

Modsite: PDECsVAkGGkMVGs SwissProt Entrez-Gene Orthologous residues ERG (human): K89‑ac, ERG iso1 (human): K96‑ac, ERG (mouse): K96‑ac, ERG iso2 (mouse): K96‑ac, ERG (cow): K89‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  BPH-1 (epithelial), HEK293T (epithelial), VCap (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes ACETYLTRANSFERASE p300 (human) siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes siRNA decrease p300 siRNA Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  carcinogenesis, induced, transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays BRD4 (human) Bromodomain Induces transcription, induced, carcinogenesis, induced co-immunoprecipitation

K92-ac - ERG (human) ▲

Modsite: CsVAkGGkMVGsPDT SwissProt Entrez-Gene Orthologous residues ERG (human): K92‑ac, ERG iso1 (human): K99‑ac, ERG (mouse): K99‑ac, ERG iso2 (mouse): K99‑ac, ERG (cow): K92‑ac Characterization Methods used to characterize site in vivo:  mutation of modification site Disease tissue studied:  prostate cancer Relevant cell lines - cell types - tissues:  BPH-1 (epithelial), HEK293T (epithelial), VCap (prostate cell) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes ACETYLTRANSFERASE p300 (human) siRNA inhibition of enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes siRNA decrease p300 siRNA Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  carcinogenesis, induced, transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays BRD4 (human) Bromodomain Induces co-immunoprecipitation