Chen CL, et al. (2016) Phosphorylation of E-cadherin at threonine 790 by protein kinase Cδ reduces β-catenin binding and suppresses the function of E-cadherin. Oncotarget 7, 37260-37276 27203386

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T790-p - CDH1 (human) ▲

Modsite: TRNDVAPtLMsVPRy SwissProt Entrez-Gene Orthologous residues CDH1 (human): T790‑p, CDH1 (mouse): T792‑p, CDH1 (rat): T794‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast), MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog Enzymes shown to modify site in vitro:  Type Enzyme KINASE PKCD (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKCD (human) pharmacological inhibitor of upstream enzyme, phospho-antibody, transfection of wild-type enzyme, activation of upstream enzyme Downstream Regulation Effect of modification (function):  activity, inhibited, molecular association, regulation Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays CTNNB1 (human) Disrupts pull-down assay CBLL1 (human) Disrupts co-immunoprecipitation Comments:  impairs homophilic interaction at cell-cell contacts

Y313-p - PKCD (human) ▲

Modsite: ssEPVGIyQGFEKkT SwissProt Entrez-Gene Orthologous residues PKCD (human): Y313‑p, PKCD iso2 (human): Y313‑p, PKCD (mouse): Y311‑p, PKCD iso2 (mouse): Y311‑p, PKCD (rat): Y311‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  CHO (fibroblast), MDCK (epithelial) Cellular systems studied:  cell lines Species studied:  dog Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes HGF increase dasatinib HGF inhibit treatment-induced increase Downstream Regulation Comments:  cell scattering