Acevedo M, et al. (2016) A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence. Cancer Res 76, 3252-64 27206849

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S127-p - DNMT1 (human) ▲
Modsite: VGMADANsPPKPLsk SwissProt Entrez-Gene Orthologous residues DNMT1 (human): S127‑p, DNMT1 iso2 (human): S127‑p, DNMT1 (mouse): R124‑p, DNMT1 (rat): R124‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro) Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK4 (human)

S154-p - DNMT1 (human) ▲
Modsite: AkPEPsPsPRITRkS SwissProt Entrez-Gene Orthologous residues DNMT1 (human): S154‑p, DNMT1 iso2 (human): S170‑p, DNMT1 (mouse): S152‑p, DNMT1 (rat): S151‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro)

S247-p - DNMT1 (human) ▲
Modsite: KEEKRLRsQTKEPTP SwissProt Entrez-Gene Orthologous residues DNMT1 (human): S247‑p, DNMT1 iso2 (human): S263‑p, DNMT1 (mouse): R243‑p, DNMT1 (rat): R243‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro)

S954-p - DNMT1 (human) ▲
Modsite: TFNIKLSsPVkRPRk SwissProt Entrez-Gene Orthologous residues DNMT1 (human): S954‑p, DNMT1 iso2 (human): S970‑p, DNMT1 (mouse): S958‑p, DNMT1 (rat): S958‑p Characterization Methods used to characterize site in vivo:  mass spectrometry (in vitro) Enzymes shown to modify site in vitro:  Type Enzyme KINASE CDK4 (human)