Joo MS, et al. (2016) AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550. Mol Cell Biol 36, 1931-42 27161318

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S550-p - NRF2 (mouse) ▲

Modsite: HLLKRRLsTLYLEVF SwissProt Entrez-Gene Orthologous residues NRF2 (human): S558‑p, NRF2 (mouse): S550‑p, NRF2 (rat): S557‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Disease tissue studied:  liver cancer Relevant cell lines - cell types - tissues:  293 (epithelial), HepG2 (hepatic) Cellular systems studied:  cell lines Species studied:  human Enzymes shown to modify site in vitro:  Type Enzyme KINASE AMPKA1 (human) Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  transcription, induced Comments:  nuclear accumulation