Shirane M, et al. (1999) Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. J Biol Chem 274, 28169-74 10497169

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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S32-p - IkB-alpha (mouse) ▲

Modsite: LVDDRHDsGLDsMKD SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S32‑p, IkB‑alpha (mouse): S32‑p, IkB‑alpha (rat): S32‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation

S36-p - IkB-alpha (mouse) ▲

Modsite: RHDsGLDsMKDEEYE SwissProt Entrez-Gene Orthologous residues IkB‑alpha (human): S36‑p, IkB‑alpha (mouse): S36‑p, IkB‑alpha (rat): S36‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation

S19-p - IkB-beta (mouse) ▲

Modsite: DADEWCDsGLGsLGP SwissProt Entrez-Gene Orthologous residues IkB‑beta (human): S19‑p, IkB‑beta (mouse): S19‑p, IkB‑beta (rat): S19‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation

S23-p - IkB-beta (mouse) ▲

Modsite: WCDsGLGsLGPDAAA SwissProt Entrez-Gene Orthologous residues IkB‑beta (human): S23‑p, IkB‑beta (mouse): S23‑p, IkB‑beta (rat): S23‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation

S18-p - IkB-epsilon (mouse) ▲

Modsite: ADDSQCDsGIEsLRS SwissProt Entrez-Gene Orthologous residues IkB‑epsilon (human): S157‑p, IkB‑epsilon (mouse): S18‑p, IkB‑epsilon (rat): S18‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation

S22-p - IkB-epsilon (mouse) ▲

Modsite: QCDsGIEsLRSLRSL SwissProt Entrez-Gene Orthologous residues IkB‑epsilon (human): S161‑p, IkB‑epsilon (mouse): S22‑p, IkB‑epsilon (rat): S22‑p Characterization Methods used to characterize site in vivo:  mutation of modification site Relevant cell lines - cell types - tissues:  HEK293T (epithelial) Cellular systems studied:  cell lines Species studied:  human Downstream Regulation Effect of modification (function):  protein degradation