Mochan TA, Venere M, DiTullio RA, Halazonetis TD (2003) 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res 63, 8586-91 14695167

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S1981-p - ATM (human) ▲

Modsite: sLAFEEGsQSTtIss SwissProt Entrez-Gene Orthologous residues ATM (human): S1981‑p, ATM (mouse): S1987‑p, ATM (rat): S1988‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), NHDF (fibroblast), SKNSH (neural crest), U2OS (bone cell) [GR (human)], XPC (fibroblast) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase Downstream Regulation Effect of modification (function):  activity, induced

S33-p - Chk2 (human) ▲

Modsite: tQsQGSSsQsQGIss SwissProt Entrez-Gene Orthologous residues Chk2 (human): S33‑p, Chk2 iso9 (human): S33‑p, Chk2 iso11 (human): S33‑p, Chk2 iso12 (human): S33‑p, Chk2 (mouse): S36‑p, Chk2 (rat): S35‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), NHDF (fibroblast), SKNSH (neural crest), U2OS (bone cell) [GR (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) antisense inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase

S35-p - Chk2 (human) ▲

Modsite: sQGSSsQsQGIssss SwissProt Entrez-Gene Orthologous residues Chk2 (human): S35‑p, Chk2 iso9 (human): S35‑p, Chk2 iso11 (human): S35‑p, Chk2 iso12 (human): S35‑p, Chk2 (mouse): L38‑p, Chk2 (rat): L37‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), NHDF (fibroblast), SKNSH (neural crest), U2OS (bone cell) [GR (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) antisense inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase

T68-p - Chk2 (human) ▲

Modsite: SsLEtVstQELYsIP SwissProt Entrez-Gene Orthologous residues Chk2 (human): T68‑p, Chk2 iso9 (human): T68‑p, Chk2 iso11 (human): T68‑p, Chk2 iso12 (human): T68‑p, Chk2 (mouse): T77‑p, Chk2 (rat): T76‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical), NHDF (fibroblast), SKNSH (neural crest), U2OS (bone cell) [GR (human)] Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) antisense inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase UV increase

S343-p - NBS1 (human) ▲

Modsite: TtPGPsLsQGVsVDE SwissProt Entrez-Gene Orthologous residues NBS1 (human): S343‑p, NBS1 (mouse): S343‑p, NBS1 (rat): S343‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) antisense inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase

S957-p - Smc1 (human) ▲

Modsite: IsQEEGssQGEDsVs SwissProt Entrez-Gene Orthologous residues Smc1 (human): S957‑p, Smc1 (mouse): S957‑p, Smc1 (rat): S957‑p Characterization Methods used to characterize site in vivo:  phospho-antibody Relevant cell lines - cell types - tissues:  NBS-ILB1 (fibroblast) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE ATM (human) antisense inhibition of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase