Kalogeropulou AF, et al. (2018) P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity. Biochem J 475, 1271-1293 29519959

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T138-p - SQSTM1 (human) ▲

Modsite: CNGPVVGtRYkCsVC SwissProt Entrez-Gene Orthologous residues SQSTM1 (human): T138‑p, SQSTM1 iso2 (human): T54‑p, SQSTM1 (mouse): T138‑p, SQSTM1 iso2 (mouse): T138‑p, SQSTM1 (rat): T135‑p, SQSTM1 iso2 (rat): T135‑p, SQSTM1 iso3 (rat): T135‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mass spectrometry, mutation of modification site, phospho-antibody, western blotting Disease tissue studied:  lung cancer, non-small cell lung cancer, non-small cell lung adenocarcinoma Relevant cell lines - cell types - tissues:  'neuron, cortical', 293 (epithelial), A549 (pulmonary) Cellular systems studied:  cell lines Species studied:  human, rat Enzymes shown to modify site in vitro:  Type Enzyme KINASE LRRK2 (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE LRRK2 (human) co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, phospho-antibody, transfection of inactive enzyme, transfection of wild-type enzyme Downstream Regulation Effect of modification (process):  apoptosis, induced