Curated Information
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Home > Curated Information Page > PubMed Id: 12165520
Kabat J, Borrego F, Brooks A, Coligan JE (2002) Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. J Immunol 169, 1948-58 12165520
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y8-p - NKG2A (human)
Modsite: MDNQGVIySDLNLPP SwissProt Entrez-Gene
Orthologous residues
NKG2A (human): Y8‑p, NKG2A (mouse): Y8‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) Induces intracellular localization co-immunoprecipitation, electrophoretic visualization

Y40-p - NKG2A (human)
Modsite: ATEQEITyAELNLQK SwissProt Entrez-Gene
Orthologous residues
NKG2A (human): Y40‑p, NKG2A (mouse): Y40‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody
Relevant cell lines - cell types - tissues:  RBL-2H3 (basophil)
Cellular systems studied:  cell lines
Species studied:  rat
Downstream Regulation
Effect of modification (function):  activity, induced, intracellular localization, molecular association, regulation
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-1 (human) Induces intracellular localization co-immunoprecipitation, electrophoretic visualization