Curated Information
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Home > Curated Information Page > PubMed Id: 27014871
Tan X, et al. (2016) Phosphoproteome Analysis of Invasion and Metastasis-Related Factors in Pancreatic Cancer Cells. PLoS One 11, e0152280 27014871
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y204-p - Abl iso2 (human)
Modsite: tASDGKLyVSSESRF SwissProt Entrez-Gene
Orthologous residues
Abl (human): Y185‑p, Abl iso2 (human): Y204‑p, Abl (mouse): Y185‑p, Abl iso4 (mouse): Y204‑p, Abl (rat): Y185‑p, Abl iso2 (rat): Y204‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

Y55-p - ACTC1 (human)
Modsite: GMGQkDsyVGDEAQs SwissProt Entrez-Gene
Orthologous residues
ACTC1 (human): Y55‑p, ACTC1 (mouse): Y55‑p, ACTC1 (rat): Y55‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

T72-p - Akt1 (human)
Modsite: tERPRPNtFIIRCLQ SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): T72‑p, Akt1 iso2 (human): T10‑p, Akt1 (mouse): T72‑p, Akt1 (rat): T72‑p, Akt1 (fruit fly): T175‑p, Akt1 (cow): T72‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster

S124-p - Akt1 (human)
Modsite: EMDFRsGsPsDNsGA SwissProt Entrez-Gene
Orthologous residues
Akt1 (human): S124‑p, Akt1 iso2 (human): S62‑p, Akt1 (mouse): S124‑p, Akt1 (rat): S124‑p, Akt1 (fruit fly): T236‑p, Akt1 (cow): S124‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

S78-p - BID (human)
Modsite: RIEADsEsQEDIIRN SwissProt Entrez-Gene
Orthologous residues
BID (human): S78‑p, BID iso2 (human): S124‑p, BID (mouse): S78‑p, BID (rat): S79‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

T177-p - CAMK1A (human)
Modsite: DPGsVLstACGTPGY SwissProt Entrez-Gene
Orthologous residues
CAMK1A (human): T177‑p, CAMK1A (mouse): T177‑p, CAMK1A (rat): T177‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

Y593-p - DDX5 (human)
Modsite: NGMNQQAyAyPATAA SwissProt Entrez-Gene
Orthologous residues
DDX5 (human): Y593‑p, DDX5 (mouse): Y593‑p, DDX5 (rat): Y593‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

T232-p - Fos (human)
Modsite: GGLPEVAtPESEEAF SwissProt Entrez-Gene
Orthologous residues
Fos (human): T232‑p, Fos (mouse): T232‑p, Fos (rat): T232‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S21-p - GRK1 (human)
Modsite: AFIAARGsFDGSSSQ SwissProt Entrez-Gene
Orthologous residues
GRK1 (human): S21‑p, GRK1 (mouse): S21‑p, GRK1 (rat): S21‑p, GRK1 (cow): S21‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

S636-p - IRS1 (human)
Modsite: sGDyMPMsPKsVSAP SwissProt Entrez-Gene
Orthologous residues
IRS1 (human): S636‑p, IRS1 (mouse): S632‑p, IRS1 (rat): S632‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

Y1510-p - ITGB4 (human)
Modsite: sttLPRDystLtsVs SwissProt Entrez-Gene
Orthologous residues
ITGB4 (human): Y1510‑p, ITGB4 iso2 (human): Y1440‑p, ITGB4 iso3 (human): Y1440‑p, ITGB4 (mouse): Y1506‑p, ITGB4 iso2 (mouse): Y1441‑p, ITGB4 iso3 (mouse): Y1441‑p, ITGB4 (rat): Y1441‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S432-p - K8 (human)
Modsite: sAyGGLtsPGLsysL SwissProt Entrez-Gene
Orthologous residues
K8 (human): S432‑p, K8 iso2 (human): S460‑p, K8 (mouse): S438‑p, K8 (rat): S432‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

S392-p - lamin A/C (human)
Modsite: ErLRLsPsPtsQRsR SwissProt Entrez-Gene
Orthologous residues
lamin A/C (human): S392‑p, lamin A/C iso2 (human): S392‑p, lamin A/C iso3 (human): S392‑p, lamin A/C (mouse): S392‑p, lamin A/C iso3 (mouse): S280‑p, lamin A/C (rat): S392‑p, lamin A/C (cow): S392‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S376-p - MSK1 (human)
Modsite: EKLFQGysFVAPsIL SwissProt Entrez-Gene
Orthologous residues
MSK1 (human): S376‑p, MSK1 (mouse): S375‑p, MSK1 (rat): S329‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S62-p - Myc (human)
Modsite: LLPtPPLsPsRRsGL SwissProt Entrez-Gene
Orthologous residues
Myc (human): S62‑p, Myc iso2 (human): S77‑p, Myc (mouse): S62‑p, Myc (rat): S62‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S371-p - p70S6K iso2 (human)
Modsite: TRQTPVDsPDDSTLS SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): S394‑p, p70S6K iso2 (human): S371‑p, p70S6K (mouse): S394‑p, p70S6K (rat): S394‑p, p70S6K iso2 (rat): S371‑p, p70S6K (fruit fly): S380‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S418-p - p70S6K iso2 (human)
Modsite: SPRRFIGsPRtPVsP SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): S441‑p, p70S6K iso2 (human): S418‑p, p70S6K (mouse): S441‑p, p70S6K (rat): S441‑p, p70S6K iso2 (rat): S418‑p, p70S6K (fruit fly): Q425‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

T421-p - p70S6K iso2 (human)
Modsite: RFIGsPRtPVsPVKF SwissProt Entrez-Gene
Orthologous residues
p70S6K (human): T444‑p, p70S6K iso2 (human): T421‑p, p70S6K (mouse): T444‑p, p70S6K (rat): T444‑p, p70S6K iso2 (rat): T421‑p, p70S6K (fruit fly): S429‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

T573-p - p90RSK (human)
Modsite: AENGLLMtPCytANF SwissProt Entrez-Gene
Orthologous residues
p90RSK (human): T573‑p, p90RSK iso2 (human): T582‑p, p90RSK (mouse): T562‑p, p90RSK iso3 (mouse): , p90RSK (rat): T573‑p, p90RSK (chicken): T590‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

Y849-p - PDGFRA (human)
Modsite: DIMHDsNyVsKGSTF SwissProt Entrez-Gene
Orthologous residues
PDGFRA (human): Y849‑p, PDGFRA (mouse): Y849‑p, PDGFRA (rat): Y848‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

Y753-p - PLCG2 (human)
Modsite: ERDINSLyDVsRMyV SwissProt Entrez-Gene
Orthologous residues
PLCG2 (human): Y753‑p, PLCG2 (mouse): Y753‑p, PLCG2 (rat): Y753‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S296-p - RAF1 (human)
Modsite: sPsALsssPNNLsPt SwissProt Entrez-Gene
Orthologous residues
RAF1 (human): S296‑p, RAF1 iso2 (human): S316‑p, RAF1 (mouse): S296‑p, RAF1 (rat): S296‑p, RAF1 (chicken): S296‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

Y341-p - RAF1 (human)
Modsite: GQRDssyyWEIEASE SwissProt Entrez-Gene
Orthologous residues
RAF1 (human): Y341‑p, RAF1 iso2 (human): Y361‑p, RAF1 (mouse): Y341‑p, RAF1 (rat): Y341‑p, RAF1 (chicken): Y341‑p
Characterization
Methods used to characterize site in vivo phospho-antibody, western blotting
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma increased

S187-p - SMAD1 (human)
Modsite: NSHPFPHsPNSSYPN SwissProt Entrez-Gene
Orthologous residues
SMAD1 (human): S187‑p, SMAD1 (mouse): S187‑p, SMAD1 (rat): S187‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

T220-p - SMAD2 (human)
Modsite: QSNYIPEtPPPGYIS SwissProt Entrez-Gene
Orthologous residues
SMAD2 (human): T220‑p, SMAD2 (mouse): T220‑p, SMAD2 (rat): T220‑p, SMAD2 (cow): T220‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased

S250-p - SMAD2 (human)
Modsite: TGsPAELsPTTLsPV SwissProt Entrez-Gene
Orthologous residues
SMAD2 (human): S250‑p, SMAD2 (mouse): S250‑p, SMAD2 (rat): S250‑p, SMAD2 (cow): S250‑p
Characterization
Methods used to characterize site in vivo phospho-antibody
Disease tissue studied:  pancreatic cancer
Relevant cell lines - cell types - tissues:  PC-1 (pancreatic), PC1.0 (pancreatic)
Cellular systems studied:  cell lines
Species studied:  hamster
Associated Diseases
Diseases Alterations Comments
pancreatic ductal adenocarcinoma decreased