Curated Information
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Home > Curated Information Page > PubMed Id: 26868487
Llorens MC, et al. (2016) Phosphorylation Regulates Functions of ZEB1 Transcription Factor. J Cell Physiol 231, 2205-17 26868487
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T867-p - TCF8 (rat)
Modsite: DQNDSDCtPPKKKTR SwissProt Entrez-Gene
Orthologous residues
TCF8 (human): T890‑p, TCF8 iso2 (human): T891‑p, TCF8 (mouse): T868‑p, TCF8 (rat): T867‑p
Characterization
Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  CHO-K1 (fibroblast), COS7 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  hamster
Upstream Regulation
Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ERK2 (human) modification site within consensus motif, pharmacological inhibitor of upstream enzyme, activation of upstream enzyme, phospho-antibody
KINASE ERK1 (human) modification site within consensus motif, pharmacological inhibitor of upstream enzyme, activation of upstream enzyme, phospho-antibody
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IGF-1 increase
Downstream Regulation
Effect of modification (function):  intracellular localization
Effect of modification (process):  transcription, induced
Comments:  disrrupts nuclear localization