Olivito L, et al. (2016) Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity. Brain Struct Funct 221, 591-603 25381005

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

Download

S849-p - GluR1 (mouse) ▲

Modsite: FCLIPQQsINEAIRt SwissProt Entrez-Gene Orthologous residues GluR1 (human): S849‑p, GluR1 iso6 (human): S859‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, hippocampus' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CAMK2A (mouse) activation of upstream enzyme, pharmacological inhibitor of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes learning increase autocamtide_inhibitory_peptide learning inhibit treatment-induced increase Downstream Regulation Comments:  memory capacity

S863-p - GluR1 (mouse) ▲

Modsite: tstLPRNsGAGASGG SwissProt Entrez-Gene Orthologous residues GluR1 (human): S863‑p, GluR1 iso6 (human): S873‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p Characterization Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'brain, hippocampus' Cellular systems studied:  tissue Species studied:  mouse Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE PKACA (mouse) activation of upstream enzyme, pharmacological activator of upstream enzyme Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes learning increase Rp-cAMPS learning inhibit treatment-induced increase Downstream Regulation Comments:  memory capacity