Curated Information
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Home > Curated Information Page > PubMed Id: 23846654
Zheng Y, et al. (2013) Temporal regulation of EGF signalling networks by the scaffold protein Shc1. Nature 499, 166-71 23846654
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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T694-p - EGFR (rat)
Modsite: RELVEPLtPSGEAPN SwissProt Entrez-Gene
Orthologous residues
EGFR (human): T693‑p, EGFR iso2 (human): , EGFR iso5 (human): T693‑p, EGFR (mouse): T695‑p, EGFR (rat): T694‑p, EGFR (pig): T693‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y1109-p - EGFR (rat)
Modsite: GsVQNPVyHNQPLHP SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1110‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1110‑p, EGFR (rat): Y1109‑p, EGFR (pig): Y1109‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y1171-p - EGFR (rat)
Modsite: MSLDNPDyQQDFFPK SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1172‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1172‑p, EGFR (rat): Y1171‑p, EGFR (pig): Y1171‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y1196-p - EGFR (rat)
Modsite: PTAENAEyLRVAPPS SwissProt Entrez-Gene
Orthologous residues
EGFR (human): Y1197‑p, EGFR iso2 (human): , EGFR iso5 (human): , EGFR (mouse): Y1197‑p, EGFR (rat): Y1196‑p, EGFR (pig): Y1196‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S250-p - GAB1 (rat)
Modsite: CPPPRVTsVSGEsGL SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S251‑p, GAB1 iso2 (human): S251‑p, GAB1 (mouse): S251‑p, GAB1 (rat): S250‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S265-p - GAB1 (rat)
Modsite: yNLPRSYsHDVLPKE SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S266‑p, GAB1 iso2 (human): S266‑p, GAB1 (mouse): S266‑p, GAB1 (rat): S265‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

T386-p - GAB1 (rat)
Modsite: MPPSRSNtISTVDLN SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): T387‑p, GAB1 iso2 (human): T387‑p, GAB1 (mouse): T388‑p, GAB1 (rat): T386‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S418-p - GAB1 (rat)
Modsite: FPSDRSSsLEGFHNQ SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S419‑p, GAB1 iso2 (human): S419‑p, GAB1 (mouse): S420‑p, GAB1 (rat): S418‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S453-p - GAB1 (rat)
Modsite: YVPMNPNsPPRHHPS SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S454‑p, GAB1 iso2 (human): S454‑p, GAB1 (mouse): S455‑p, GAB1 (rat): S453‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S550-p - GAB1 (rat)
Modsite: ELQAPVRsPITRSFA SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): S551‑p, GAB1 iso2 (human): S581‑p, GAB1 (mouse): S552‑p, GAB1 (rat): S550‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y626-p - GAB1 (rat)
Modsite: KGDKQVEyLDLDLES SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): Y627‑p, GAB1 iso2 (human): Y657‑p, GAB1 (mouse): Y628‑p, GAB1 (rat): Y626‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y658-p - GAB1 (rat)
Modsite: MSDERVDyVVVDQQK SwissProt Entrez-Gene
Orthologous residues
GAB1 (human): Y659‑p, GAB1 iso2 (human): Y689‑p, GAB1 (mouse): Y660‑p, GAB1 (rat): Y658‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S143-p - GAB2 (rat)
Modsite: ASHGPRssPAEFSSS SwissProt Entrez-Gene
Orthologous residues
GAB2 (human): S141‑p, GAB2 iso2 (human): S103‑p, GAB2 (mouse): S143‑p, GAB2 (rat): S143‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y1198-p - HER2 (rat)
Modsite: GAVENPEyLVPREGT SwissProt Entrez-Gene
Orthologous residues
HER2 (human): Y1196‑p, HER2 iso2 (human): Y586‑p, HER2 iso5 (human): Y1166‑p, HER2 (mouse): Y1197‑p, HER2 (rat): Y1198‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S250-p - MIG-6 (rat)
Modsite: RRLRRsHsGPAGSFN SwissProt Entrez-Gene
Orthologous residues
MIG‑6 (human): S251‑p, MIG‑6 (mouse): S251‑p, MIG‑6 (rat): S250‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S139-p - SHC1 (rat)
Modsite: EEWTRHGsFVNKPTR SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): S139‑p, SHC1 iso2 (human): S29‑p, SHC1 iso3 (human): , SHC1 iso6 (human): S139‑p, SHC1 iso7 (human): S29‑p, SHC1 (mouse): S139‑p, SHC1 iso2 (mouse): S29‑p, SHC1 iso3 (mouse): , SHC1 (rat): S139‑p, SHC1 iso2 (rat): S29‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

T324-p - SHC1 (rat)
Modsite: RNPPKLVtPHDRMAG SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): T324‑p, SHC1 iso2 (human): T214‑p, SHC1 iso3 (human): T169‑p, SHC1 iso6 (human): T324‑p, SHC1 iso7 (human): T214‑p, SHC1 (mouse): T324‑p, SHC1 iso2 (mouse): T214‑p, SHC1 iso3 (mouse): T169‑p, SHC1 (rat): T324‑p, SHC1 iso2 (rat): T214‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y349-p - SHC1 (rat)
Modsite: EEPPDHQyyNDFPGK SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): Y349‑p, SHC1 iso2 (human): Y239‑p, SHC1 iso3 (human): Y194‑p, SHC1 iso6 (human): Y349‑p, SHC1 iso7 (human): Y239‑p, SHC1 (mouse): Y349‑p, SHC1 iso2 (mouse): Y239‑p, SHC1 iso3 (mouse): Y194‑p, SHC1 (rat): Y349‑p, SHC1 iso2 (rat): Y239‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y350-p - SHC1 (rat)
Modsite: EPPDHQyyNDFPGKE SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): Y350‑p, SHC1 iso2 (human): Y240‑p, SHC1 iso3 (human): Y195‑p, SHC1 iso6 (human): Y350‑p, SHC1 iso7 (human): Y240‑p, SHC1 (mouse): Y350‑p, SHC1 iso2 (mouse): Y240‑p, SHC1 iso3 (mouse): Y195‑p, SHC1 (rat): Y350‑p, SHC1 iso2 (rat): Y240‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

Y423-p - SHC1 (rat)
Modsite: ELFDDPSyVNIQNLD SwissProt Entrez-Gene
Orthologous residues
SHC1 (human): Y427‑p, SHC1 iso2 (human): Y317‑p, SHC1 iso3 (human): Y272‑p, SHC1 iso6 (human): Y428‑p, SHC1 iso7 (human): Y318‑p, SHC1 (mouse): Y423‑p, SHC1 iso2 (mouse): Y313‑p, SHC1 iso3 (mouse): Y268‑p, SHC1 (rat): Y423‑p, SHC1 iso2 (rat): Y313‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S1196-p - SOS1 (rat)
Modsite: SISDPPEsPPLLPPR GenPept Entrez-Gene
Orthologous residues
SOS1 (human): S1210‑p, SOS1 (mouse): S1196‑p, SOS1 (rat): S1196‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat

S1261-p - SOS1 (rat)
Modsite: GTRRHLPsPPLTQEV GenPept Entrez-Gene
Orthologous residues
SOS1 (human): S1275‑p, SOS1 (mouse): S1261‑p, SOS1 (rat): S1261‑p
Characterization
Methods used to characterize site in vivo mass spectrometry
Relevant cell lines - cell types - tissues:  Rat2 (fibroblast)
Cellular systems studied:  cell lines
Species studied:  rat