Fortugno P, et al. (2002) Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function. J Cell Sci 115, 575-85 11861764

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T34-p - Survivin (human) ▲

Modsite: FLEGCACtPERMAEA SwissProt Entrez-Gene Orthologous residues Survivin (human): T34‑p, Survivin iso2 (human): T34‑p, Survivin (mouse): T34‑p, Survivin iso2 (mouse): T34‑p, Survivin (rat): T34‑p Characterization Methods used to characterize site in vivo:  microscopy-colocalization with upstream kinase, phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  HeLa (cervical) Cellular systems studied:  cell lines Species studied:  human Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE CDK1 (human) co-immunoprecipitation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes taxol increase Phosphorylated survivin was associated with p34cdc2 in taxol arrested cells. Downstream Regulation Effect of modification (function):  intracellular localization Effect of modification (process):  cytoskeletal reorganization Comments:  nuclear and cytopasmic pools of survivin differentially localized and associated with microrubles during mitosis