Curated Information
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Home > Curated Information Page > PubMed Id: 26740630
Shin HR, et al. (2016) Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem 291, 5555-65 26740630
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S191-p - CTNNB1 (human)
Modsite: SRHAIMRsPQMVsAI SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S191‑p, CTNNB1 (mouse): S191‑p, CTNNB1 (rat): S191‑p, CTNNB1 (rabbit): S191‑p
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation
Comments:  nuclear retention

S246-p - CTNNB1 (human)
Modsite: ALVKMLGsPVDSVLF SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S246‑p, CTNNB1 (mouse): S246‑p, CTNNB1 (rat): S246‑p, CTNNB1 (rabbit): S246‑p
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation
Comments:  nuclear retention

S605-p - CTNNB1 (human)
Modsite: LFVQLLYsPIENIQR SwissProt Entrez-Gene
Orthologous residues
CTNNB1 (human): S605‑p, CTNNB1 (mouse): S605‑p, CTNNB1 (rat): S605‑p, CTNNB1 (rabbit): S605‑p
Downstream Regulation
Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization
Effect of modification (process):  transcription, induced
Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIN1 (human) Induces co-immunoprecipitation
Comments:  nuclear retention