Shin HR, et al. (2016) Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. J Biol Chem 291, 5555-65 26740630

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

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S191-p - CTNNB1 (human) ▲

Modsite: sRHAIMRsPQMVsAI SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S191‑p, CTNNB1 (mouse): S191‑p, CTNNB1 (rat): S191‑p, CTNNB1 (rabbit): S191‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), MC3T3-E1 (preosteoblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIN1 (human) Induces co-immunoprecipitation Comments:  nuclear retention

S246-p - CTNNB1 (human) ▲

Modsite: ALVKMLGsPVDSVLF SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S246‑p, CTNNB1 (mouse): S246‑p, CTNNB1 (rat): S246‑p, CTNNB1 (rabbit): S246‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), MC3T3-E1 (preosteoblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIN1 (human) Induces co-immunoprecipitation Comments:  nuclear retention

S605-p - CTNNB1 (human) ▲

Modsite: LFVQLLYsPIENIQR SwissProt Entrez-Gene Orthologous residues CTNNB1 (human): S605‑p, CTNNB1 (mouse): S605‑p, CTNNB1 (rat): S605‑p, CTNNB1 (rabbit): S605‑p Characterization Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  293 (epithelial), MC3T3-E1 (preosteoblast) Cellular systems studied:  cell lines Species studied:  human, mouse Downstream Regulation Effect of modification (function):  intracellular localization, molecular association, regulation, protein conformation, protein stabilization Effect of modification (process):  transcription, induced Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays PIN1 (human) Induces co-immunoprecipitation Comments:  nuclear retention