Curated Information
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Home > Curated Information Page > PubMed Id: 29590626
Zhang JH, et al. (2018) DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. Cell Rep 22, 3598-3611 29590626
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1420-p - DCC (human)
Modsite: TEDSANVyEQDDLSE SwissProt Entrez-Gene
Orthologous residues
DCC (human): Y1420‑p, DCC (mouse): Y1420‑p, DCC (rat): Y1418‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat

Y185-p - DAB1 (mouse)
Modsite: KQCEQAVyQTILEED SwissProt Entrez-Gene
Orthologous residues
DAB1 (human): Y185‑p, DAB1 (mouse): Y185‑p, DAB1 iso2 (mouse): Y185‑p, DAB1 iso3 (mouse): Y185‑p, DAB1 (rat): Y185‑p, DAB1 (pig): Y185‑p, DAB1 iso1 (pig): Y185‑p, DAB1 (chicken): Y185‑p, DAB1 iso2 (chicken): Y185‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat

Y198-p - DAB1 (mouse)
Modsite: EDVEDPVyQyIVFEA SwissProt Entrez-Gene
Orthologous residues
DAB1 (human): Y198‑p, DAB1 (mouse): Y198‑p, DAB1 iso2 (mouse): Y198‑p, DAB1 iso3 (mouse): Y198‑p, DAB1 (rat): Y198‑p, DAB1 (pig): Y198‑p, DAB1 iso1 (pig): , DAB1 (chicken): Y198‑p, DAB1 iso2 (chicken):
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat

Y200-p - DAB1 (mouse)
Modsite: VEDPVyQyIVFEAGH SwissProt Entrez-Gene
Orthologous residues
DAB1 (human): Y200‑p, DAB1 (mouse): Y200‑p, DAB1 iso2 (mouse): Y200‑p, DAB1 iso3 (mouse): Y200‑p, DAB1 (rat): Y200‑p, DAB1 (pig): Y200‑p, DAB1 iso1 (pig): , DAB1 (chicken): Y200‑p, DAB1 iso2 (chicken):
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat

Y220-p - DAB1 (mouse)
Modsite: PETEENIyQVPTSQK SwissProt Entrez-Gene
Orthologous residues
DAB1 (human): Y220‑p, DAB1 (mouse): Y220‑p, DAB1 iso2 (mouse): Y220‑p, DAB1 iso3 (mouse): Y220‑p, DAB1 (rat): Y220‑p, DAB1 (pig): Y220‑p, DAB1 iso1 (pig): , DAB1 (chicken): Y220‑p, DAB1 iso2 (chicken):
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
netrin-1 increase

Y232-p - DAB1 (mouse)
Modsite: SQKKEGVyDVPKSQP SwissProt Entrez-Gene
Orthologous residues
DAB1 (human): Y232‑p, DAB1 (mouse): Y232‑p, DAB1 iso2 (mouse): Y232‑p, DAB1 iso3 (mouse): Y232‑p, DAB1 (rat): Y232‑p, DAB1 (pig): Y232‑p, DAB1 iso1 (pig): Y197‑p, DAB1 (chicken): Y232‑p, DAB1 iso2 (chicken): Y197‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
Relevant cell lines - cell types - tissues:  'neuron, cortical', 293T (epithelial)
Cellular systems studied:  primary cells
Species studied:  rat
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
netrin-1 increase