Curated Information
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Home > Curated Information Page > PubMed Id: 29511123
Tang CH, et al. (2018) Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. J Cell Biol 29511123
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.
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S729-p - IRE1 (mouse)
Modsite: RHsFSRRsGVPGTEG SwissProt Entrez-Gene
Orthologous residues
IRE1 (human): S729‑p, IRE1 (mouse): S729‑p
Characterization
Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody, western blotting
Disease tissue studied:  lymphoma, B cell lymphoma, multiple myeloma
Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), B lymphocyte-spleen, NCI-H929 (B lymphocyte)
Cellular systems studied:  cell lines, primary cells
Species studied:  mouse
Upstream Regulation
Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
XBP1 (mouse) decrease XBP1 -/- increase
DTT increase
SubAB increase
Shiga_toxin no change compared to control
PTX no change compared to control
Downstream Regulation
Effect of modification (process):  RNA splicing, induced
Comments:  expression of spliced XBP1; RE1-dependent decay (RIDD) of other mRNAs